| Regular Season: Week 1 |
 Browns |
at |
 Chiefs |
Sunday, September 4, 1988 |
3:00PM |
CLE 6, KC 3 |
| Regular Season: Week 2 |
Chiefs |
at |
 Seahawks |
Sunday, September 11, 1988 |
3:00PM |
KC 10, SEA 31 |
| Regular Season: Week 3 |
 Broncos |
at |
Chiefs |
Sunday, September 18, 1988 |
3:00PM |
DEN 13, KC 20 |
| Regular Season: Week 4 |
 Chargers |
at |
Chiefs |
Sunday, September 25, 1988 |
3:00PM |
SD 24, KC 23 |
| Regular Season: Week 5 |
Chiefs |
at |
 Jets |
Sunday, October 2, 1988 |
3:00PM |
KC 17, NYJ 17 |
| Regular Season: Week 6 |
Chiefs |
at |
 Oilers |
Sunday, October 9, 1988 |
3:00PM |
KC 6, HOU 7 |
| Regular Season: Week 7 |
 Raiders |
at |
Chiefs |
Sunday, October 16, 1988 |
3:00PM |
RAI 27, KC 17 |
| Regular Season: Week 8 |
 Lions |
at |
Chiefs |
Sunday, October 23, 1988 |
3:00PM |
DET 7, KC 6 |
| Regular Season: Week 9 |
Chiefs |
at |
Raiders |
Sunday, October 30, 1988 |
2:00PM |
KC 10, RAI 17 |
| Regular Season: Week 10 |
Chiefs |
at |
Broncos |
Sunday, November 6, 1988 |
3:00PM |
KC 11, DEN 17 |
| Regular Season: Week 11 |
 Bengals |
at |
Chiefs |
Sunday, November 13, 1988 |
3:00PM |
CIN 28, KC 31 |
| Regular Season: Week 12 |
Seahawks |
at |
Chiefs |
Sunday, November 20, 1988 |
3:00PM |
SEA 24, KC 27 |
| Regular Season: Week 13 |
Chiefs |
at |
 Steelers |
Sunday, November 27, 1988 |
3:00PM |
KC 10, PIT 16 |
| Regular Season: Week 14 |
Jets |
at |
Chiefs |
Sunday, December 4, 1988 |
3:00PM |
NYJ 34, KC 38 |
| Regular Season: Week 15 |
Chiefs |
at |
 Giants |
Sunday, December 11, 1988 |
3:00PM |
KC 12, NYG 28 |
| Regular Season: Week 16 |
Chiefs |
at |
Chargers |
Sunday, December 18, 1988 |
3:00PM |
KC 13, SD 24 |