| Regular Season: Week 1 |
 Colts |
at |
 Chiefs |
Sunday, September 3, 2000 |
1:00PM |
IND 27, KC 14 |
| Regular Season: Week 2 |
Chiefs |
at |
 Titans |
Sunday, September 10, 2000 |
1:00PM |
KC 14, TEN 17 |
| Regular Season: Week 3 |
 Chargers |
at |
Chiefs |
Sunday, September 17, 2000 |
1:00PM |
SD 10, KC 42 |
| Regular Season: Week 4 |
Chiefs |
at |
 Broncos |
Sunday, September 24, 2000 |
4:15PM |
KC 23, DEN 22 |
| Regular Season: Week 5 |
 Seahawks |
at |
Chiefs |
Monday, October 2, 2000 |
9:00PM |
SEA 17, KC 24 |
| Regular Season: Week 7 |
 Raiders |
at |
Chiefs |
Sunday, October 15, 2000 |
1:00PM |
OAK 20, KC 17 |
| Regular Season: Week 8 |
 Rams |
at |
Chiefs |
Sunday, October 22, 2000 |
1:00PM |
STL 34, KC 54 |
| Regular Season: Week 9 |
Chiefs |
at |
Seahawks |
Sunday, October 29, 2000 |
4:15PM |
KC 24, SEA 19 |
| Regular Season: Week 10 |
Chiefs |
at |
Raiders |
Sunday, November 5, 2000 |
4:15PM |
KC 31, OAK 49 |
| Regular Season: Week 11 |
Chiefs |
at |
 49ers |
Sunday, November 12, 2000 |
4:05PM |
KC 7, SF 21 |
| Regular Season: Week 12 |
 Bills |
at |
Chiefs |
Sunday, November 19, 2000 |
1:00PM |
BUF 21, KC 17 |
| Regular Season: Week 13 |
Chiefs |
at |
Chargers |
Sunday, November 26, 2000 |
4:15PM |
KC 16, SD 17 |
| Regular Season: Week 14 |
Chiefs |
at |
 Patriots |
Monday, December 4, 2000 |
9:00PM |
KC 24, NE 30 |
| Regular Season: Week 15 |
 Panthers |
at |
Chiefs |
Sunday, December 10, 2000 |
1:00PM |
CAR 14, KC 15 |
| Regular Season: Week 16 |
Broncos |
at |
Chiefs |
Sunday, December 17, 2000 |
1:00PM |
DEN 7, KC 20 |
| Regular Season: Week 17 |
Chiefs |
at |
 Falcons |
Sunday, December 24, 2000 |
1:00PM |
KC 13, ATL 29 |