| Regular Season: Week 1 |
 Browns |
at |
 Chiefs |
Sunday, September 12, 2021 |
4:25PM |
CLE 29, KC 33 |
| Regular Season: Week 2 |
Chiefs |
at |
 Ravens |
Sunday, September 19, 2021 |
8:20PM |
KC 35, BAL 36 |
| Regular Season: Week 3 |
 Chargers |
at |
Chiefs |
Sunday, September 26, 2021 |
1:00PM |
LAC 30, KC 24 |
| Regular Season: Week 4 |
Chiefs |
at |
 Eagles |
Sunday, October 3, 2021 |
1:00PM |
KC 42, PHI 30 |
| Regular Season: Week 5 |
 Bills |
at |
Chiefs |
Sunday, October 10, 2021 |
8:20PM |
BUF 38, KC 20 |
| Regular Season: Week 6 |
Chiefs |
at |
 Washington |
Sunday, October 17, 2021 |
1:00PM |
KC 31, WSH 13 |
| Regular Season: Week 7 |
Chiefs |
at |
 Titans |
Sunday, October 24, 2021 |
1:00PM |
KC 3, TEN 27 |
| Regular Season: Week 8 |
 Giants |
at |
Chiefs |
Monday, November 1, 2021 |
8:15PM |
NYG 17, KC 20 |
| Regular Season: Week 9 |
 Packers |
at |
Chiefs |
Sunday, November 7, 2021 |
4:25PM |
GB 7, KC 13 |
| Regular Season: Week 10 |
Chiefs |
at |
 Raiders |
Sunday, November 14, 2021 |
8:20PM |
KC 41, LV 14 |
| Regular Season: Week 11 |
 Cowboys |
at |
Chiefs |
Sunday, November 21, 2021 |
4:25PM |
DAL 9, KC 19 |
| Regular Season: Week 13 |
 Broncos |
at |
Chiefs |
Sunday, December 5, 2021 |
1:00PM |
DEN 9, KC 22 |
| Regular Season: Week 14 |
Raiders |
at |
Chiefs |
Sunday, December 12, 2021 |
1:00PM |
LV 9, KC 48 |
| Regular Season: Week 15 |
Chiefs |
at |
Chargers |
Thursday, December 16, 2021 |
8:20PM |
KC 34, LAC 28 |
| Regular Season: Week 16 |
 Steelers |
at |
Chiefs |
Sunday, December 26, 2021 |
4:25PM |
PIT 10, KC 36 |
| Regular Season: Week 17 |
Chiefs |
at |
 Bengals |
Sunday, January 2, 2022 |
1:00PM |
KC 31, CIN 34 |
| Regular Season: Week 18 |
Chiefs |
at |
Broncos |
Sunday, January 9, 2022 |
4:25PM |
KC 28, DEN 24 |