| Regular Season: Week 1 |
 Colts |
at |
 Cowboys |
Monday, September 4, 1978 |
3:00PM |
BAL 0, DAL 38 |
| Regular Season: Week 2 |
 Dolphins |
at |
Colts |
Sunday, September 10, 1978 |
3:00PM |
MIA 42, BAL 0 |
| Regular Season: Week 3 |
Colts |
at |
 Patriots |
Monday, September 18, 1978 |
3:00PM |
BAL 34, NE 27 |
| Regular Season: Week 4 |
Colts |
at |
 Bills |
Sunday, September 24, 1978 |
3:00PM |
BAL 17, BUF 24 |
| Regular Season: Week 5 |
 Eagles |
at |
Colts |
Sunday, October 1, 1978 |
3:00PM |
PHI 17, BAL 14 |
| Regular Season: Week 6 |
Colts |
at |
 Cardinals |
Sunday, October 8, 1978 |
3:00PM |
BAL 30, STL 17 |
| Regular Season: Week 7 |
 Jets |
at |
Colts |
Sunday, October 15, 1978 |
3:00PM |
NYJ 33, BAL 10 |
| Regular Season: Week 8 |
 Broncos |
at |
Colts |
Sunday, October 22, 1978 |
3:00PM |
DEN 6, BAL 7 |
| Regular Season: Week 9 |
Colts |
at |
Dolphins |
Sunday, October 29, 1978 |
2:00PM |
BAL 8, MIA 26 |
| Regular Season: Week 10 |
 Redskins |
at |
Colts |
Monday, November 6, 1978 |
3:00PM |
WAS 17, BAL 21 |
| Regular Season: Week 11 |
Colts |
at |
 Seahawks |
Sunday, November 12, 1978 |
3:00PM |
BAL 17, SEA 14 |
| Regular Season: Week 12 |
 Browns |
at |
Colts |
Sunday, November 19, 1978 |
3:00PM |
CLE 45, BAL 24 |
| Regular Season: Week 13 |
Patriots |
at |
Colts |
Sunday, November 26, 1978 |
3:00PM |
NE 35, BAL 14 |
| Regular Season: Week 14 |
Colts |
at |
Jets |
Sunday, December 3, 1978 |
3:00PM |
BAL 16, NYJ 24 |
| Regular Season: Week 15 |
Colts |
at |
 Steelers |
Saturday, December 9, 1978 |
3:00PM |
BAL 13, PIT 35 |
| Regular Season: Week 16 |
Bills |
at |
Colts |
Sunday, December 17, 1978 |
3:00PM |
BUF 21, BAL 14 |