| Regular Season: Week 1 |
 Colts |
at |
 Jets |
Sunday, September 7, 1980 |
3:00PM |
BAL 17, NYJ 14 |
| Regular Season: Week 2 |
 Steelers |
at |
Colts |
Sunday, September 14, 1980 |
3:00PM |
PIT 20, BAL 17 |
| Regular Season: Week 3 |
Colts |
at |
 Oilers |
Sunday, September 21, 1980 |
3:00PM |
BAL 16, HOU 21 |
| Regular Season: Week 4 |
Jets |
at |
Colts |
Sunday, September 28, 1980 |
3:00PM |
NYJ 21, BAL 35 |
| Regular Season: Week 5 |
Colts |
at |
 Dolphins |
Sunday, October 5, 1980 |
3:00PM |
BAL 30, MIA 17 |
| Regular Season: Week 6 |
Colts |
at |
 Bills |
Sunday, October 12, 1980 |
3:00PM |
BAL 17, BUF 12 |
| Regular Season: Week 7 |
 Patriots |
at |
Colts |
Sunday, October 19, 1980 |
3:00PM |
NE 37, BAL 21 |
| Regular Season: Week 8 |
 Cardinals |
at |
Colts |
Sunday, October 26, 1980 |
2:00PM |
STL 17, BAL 10 |
| Regular Season: Week 9 |
Colts |
at |
 Chiefs |
Sunday, November 2, 1980 |
3:00PM |
BAL 31, KC 24 |
| Regular Season: Week 10 |
 Browns |
at |
Colts |
Sunday, November 9, 1980 |
3:00PM |
CLE 28, BAL 27 |
| Regular Season: Week 11 |
Colts |
at |
 Lions |
Sunday, November 16, 1980 |
3:00PM |
BAL 10, DET 9 |
| Regular Season: Week 12 |
Colts |
at |
Patriots |
Sunday, November 23, 1980 |
3:00PM |
BAL 21, NE 47 |
| Regular Season: Week 13 |
Bills |
at |
Colts |
Sunday, November 30, 1980 |
3:00PM |
BUF 24, BAL 28 |
| Regular Season: Week 14 |
Colts |
at |
 Bengals |
Sunday, December 7, 1980 |
3:00PM |
BAL 33, CIN 34 |
| Regular Season: Week 15 |
Dolphins |
at |
Colts |
Sunday, December 14, 1980 |
3:00PM |
MIA 24, BAL 14 |
| Regular Season: Week 16 |
Chiefs |
at |
Colts |
Sunday, December 21, 1980 |
3:00PM |
KC 38, BAL 28 |