| Regular Season: Week 1 |
 Oilers |
at |
 Colts |
Sunday, September 4, 1988 |
3:00PM |
HOU 17, IND 14 |
| Regular Season: Week 2 |
 Bears |
at |
Colts |
Sunday, September 11, 1988 |
3:00PM |
CHI 17, IND 13 |
| Regular Season: Week 3 |
Colts |
at |
 Browns |
Monday, September 19, 1988 |
3:00PM |
IND 17, CLE 23 |
| Regular Season: Week 4 |
 Dolphins |
at |
Colts |
Sunday, September 25, 1988 |
3:00PM |
MIA 13, IND 15 |
| Regular Season: Week 5 |
Colts |
at |
 Patriots |
Sunday, October 2, 1988 |
3:00PM |
IND 17, NE 21 |
| Regular Season: Week 6 |
Colts |
at |
 Bills |
Sunday, October 9, 1988 |
3:00PM |
IND 23, BUF 34 |
| Regular Season: Week 7 |
 Buccaneers |
at |
Colts |
Sunday, October 16, 1988 |
3:00PM |
TB 31, IND 35 |
| Regular Season: Week 8 |
Colts |
at |
 Chargers |
Sunday, October 23, 1988 |
3:00PM |
IND 16, SD 0 |
| Regular Season: Week 9 |
 Broncos |
at |
Colts |
Monday, October 31, 1988 |
3:00PM |
DEN 23, IND 55 |
| Regular Season: Week 10 |
 Jets |
at |
Colts |
Sunday, November 6, 1988 |
3:00PM |
NYJ 14, IND 38 |
| Regular Season: Week 11 |
Colts |
at |
 Packers |
Sunday, November 13, 1988 |
3:00PM |
IND 20, GB 13 |
| Regular Season: Week 12 |
Colts |
at |
 Vikings |
Sunday, November 20, 1988 |
3:00PM |
IND 3, MIN 12 |
| Regular Season: Week 13 |
Patriots |
at |
Colts |
Sunday, November 27, 1988 |
3:00PM |
NE 21, IND 24 |
| Regular Season: Week 14 |
Colts |
at |
Dolphins |
Sunday, December 4, 1988 |
3:00PM |
IND 31, MIA 28 |
| Regular Season: Week 15 |
Colts |
at |
Jets |
Saturday, December 10, 1988 |
3:00PM |
IND 16, NYJ 34 |
| Regular Season: Week 16 |
Bills |
at |
Colts |
Sunday, December 18, 1988 |
3:00PM |
BUF 14, IND 17 |