| Regular Season: Week 1 |
 49ers |
at |
 Colts |
Sunday, September 10, 1989 |
3:00PM |
SF 30, IND 24 |
| Regular Season: Week 2 |
Colts |
at |
 Rams |
Sunday, September 17, 1989 |
3:00PM |
IND 17, RAM 31 |
| Regular Season: Week 3 |
 Falcons |
at |
Colts |
Sunday, September 24, 1989 |
3:00PM |
ATL 9, IND 13 |
| Regular Season: Week 4 |
Colts |
at |
 Jets |
Sunday, October 1, 1989 |
3:00PM |
IND 17, NYJ 10 |
| Regular Season: Week 5 |
 Bills |
at |
Colts |
Sunday, October 8, 1989 |
3:00PM |
BUF 14, IND 37 |
| Regular Season: Week 6 |
Colts |
at |
 Broncos |
Sunday, October 15, 1989 |
3:00PM |
IND 3, DEN 14 |
| Regular Season: Week 7 |
Colts |
at |
 Bengals |
Sunday, October 22, 1989 |
3:00PM |
IND 23, CIN 12 |
| Regular Season: Week 8 |
 Patriots |
at |
Colts |
Sunday, October 29, 1989 |
2:00PM |
NE 23, IND 20 |
| Regular Season: Week 9 |
Colts |
at |
 Dolphins |
Sunday, November 5, 1989 |
3:00PM |
IND 13, MIA 19 |
| Regular Season: Week 10 |
Colts |
at |
Bills |
Sunday, November 12, 1989 |
3:00PM |
IND 7, BUF 30 |
| Regular Season: Week 11 |
Jets |
at |
Colts |
Sunday, November 19, 1989 |
3:00PM |
NYJ 10, IND 27 |
| Regular Season: Week 12 |
 Chargers |
at |
Colts |
Sunday, November 26, 1989 |
3:00PM |
SD 6, IND 10 |
| Regular Season: Week 13 |
Colts |
at |
Patriots |
Sunday, December 3, 1989 |
3:00PM |
IND 16, NE 22 |
| Regular Season: Week 14 |
 Browns |
at |
Colts |
Sunday, December 10, 1989 |
3:00PM |
CLE 17, IND 23 |
| Regular Season: Week 15 |
Dolphins |
at |
Colts |
Sunday, December 17, 1989 |
3:00PM |
MIA 13, IND 42 |
| Regular Season: Week 16 |
Colts |
at |
 Saints |
Sunday, December 24, 1989 |
3:00PM |
IND 6, NO 41 |