| Regular Season: Week 1 |
 Colts |
at |
 Bills |
Sunday, September 9, 1990 |
3:00PM |
IND 10, BUF 26 |
| Regular Season: Week 2 |
 Patriots |
at |
Colts |
Sunday, September 16, 1990 |
3:00PM |
NE 16, IND 14 |
| Regular Season: Week 3 |
Colts |
at |
 Oilers |
Sunday, September 23, 1990 |
3:00PM |
IND 10, HOU 24 |
| Regular Season: Week 4 |
Colts |
at |
 Eagles |
Sunday, September 30, 1990 |
3:00PM |
IND 24, PHI 23 |
| Regular Season: Week 5 |
 Chiefs |
at |
Colts |
Sunday, October 7, 1990 |
3:00PM |
KC 19, IND 23 |
| Regular Season: Week 7 |
 Broncos |
at |
Colts |
Sunday, October 21, 1990 |
3:00PM |
DEN 27, IND 17 |
| Regular Season: Week 8 |
 Dolphins |
at |
Colts |
Sunday, October 28, 1990 |
2:00PM |
MIA 27, IND 7 |
| Regular Season: Week 9 |
 Giants |
at |
Colts |
Monday, November 5, 1990 |
3:00PM |
NYG 24, IND 7 |
| Regular Season: Week 10 |
Colts |
at |
Patriots |
Sunday, November 11, 1990 |
3:00PM |
IND 13, NE 10 |
| Regular Season: Week 11 |
 Jets |
at |
Colts |
Sunday, November 18, 1990 |
3:00PM |
NYJ 14, IND 17 |
| Regular Season: Week 12 |
Colts |
at |
 Bengals |
Sunday, November 25, 1990 |
3:00PM |
IND 34, CIN 20 |
| Regular Season: Week 13 |
Colts |
at |
 Cardinals |
Sunday, December 2, 1990 |
3:00PM |
IND 17, PHO 20 |
| Regular Season: Week 14 |
Bills |
at |
Colts |
Sunday, December 9, 1990 |
3:00PM |
BUF 31, IND 7 |
| Regular Season: Week 15 |
Colts |
at |
Jets |
Sunday, December 16, 1990 |
3:00PM |
IND 29, NYJ 21 |
| Regular Season: Week 16 |
 Redskins |
at |
Colts |
Saturday, December 22, 1990 |
3:00PM |
WAS 28, IND 35 |
| Regular Season: Week 17 |
Colts |
at |
Dolphins |
Sunday, December 30, 1990 |
3:00PM |
IND 17, MIA 23 |