| Regular Season: Week 1 |
 Patriots |
at |
 Colts |
Sunday, September 1, 1991 |
3:00PM |
NE 16, IND 7 |
| Regular Season: Week 2 |
Colts |
at |
 Dolphins |
Sunday, September 8, 1991 |
3:00PM |
IND 6, MIA 17 |
| Regular Season: Week 3 |
Colts |
at |
 Raiders |
Sunday, September 15, 1991 |
3:00PM |
IND 0, RAI 16 |
| Regular Season: Week 4 |
 Lions |
at |
Colts |
Sunday, September 22, 1991 |
3:00PM |
DET 33, IND 24 |
| Regular Season: Week 5 |
Colts |
at |
 Seahawks |
Sunday, September 29, 1991 |
3:00PM |
IND 3, SEA 31 |
| Regular Season: Week 6 |
 Steelers |
at |
Colts |
Sunday, October 6, 1991 |
3:00PM |
PIT 21, IND 3 |
| Regular Season: Week 7 |
Colts |
at |
 Bills |
Sunday, October 13, 1991 |
3:00PM |
IND 6, BUF 42 |
| Regular Season: Week 8 |
 Jets |
at |
Colts |
Sunday, October 20, 1991 |
3:00PM |
NYJ 17, IND 6 |
| Regular Season: Week 10 |
Dolphins |
at |
Colts |
Sunday, November 3, 1991 |
3:00PM |
MIA 10, IND 6 |
| Regular Season: Week 11 |
Colts |
at |
Jets |
Sunday, November 10, 1991 |
3:00PM |
IND 28, NYJ 27 |
| Regular Season: Week 12 |
 Bears |
at |
Colts |
Sunday, November 17, 1991 |
3:00PM |
CHI 31, IND 17 |
| Regular Season: Week 13 |
Colts |
at |
 Packers |
Sunday, November 24, 1991 |
3:00PM |
IND 10, GB 14 |
| Regular Season: Week 14 |
 Browns |
at |
Colts |
Sunday, December 1, 1991 |
3:00PM |
CLE 31, IND 0 |
| Regular Season: Week 15 |
Colts |
at |
Patriots |
Sunday, December 8, 1991 |
3:00PM |
IND 17, NE 23 |
| Regular Season: Week 16 |
Bills |
at |
Colts |
Sunday, December 15, 1991 |
3:00PM |
BUF 35, IND 7 |
| Regular Season: Week 17 |
Colts |
at |
 Buccaneers |
Sunday, December 22, 1991 |
3:00PM |
IND 3, TB 17 |