| Regular Season: Week 1 |
 Bills |
at |
 Colts |
Sunday, September 12, 1999 |
3:00PM |
BUF 14, IND 31 |
| Regular Season: Week 2 |
Colts |
at |
 Patriots |
Sunday, September 19, 1999 |
3:00PM |
IND 28, NE 31 |
| Regular Season: Week 3 |
Colts |
at |
 Chargers |
Sunday, September 26, 1999 |
3:00PM |
IND 27, SD 19 |
| Regular Season: Week 5 |
 Dolphins |
at |
Colts |
Sunday, October 10, 1999 |
3:00PM |
MIA 34, IND 31 |
| Regular Season: Week 6 |
Colts |
at |
 Jets |
Sunday, October 17, 1999 |
3:00PM |
IND 16, NYJ 13 |
| Regular Season: Week 7 |
 Bengals |
at |
Colts |
Sunday, October 24, 1999 |
3:00PM |
CIN 10, IND 31 |
| Regular Season: Week 8 |
 Cowboys |
at |
Colts |
Sunday, October 31, 1999 |
2:00PM |
DAL 24, IND 34 |
| Regular Season: Week 9 |
 Chiefs |
at |
Colts |
Sunday, November 7, 1999 |
3:00PM |
KC 17, IND 25 |
| Regular Season: Week 10 |
Colts |
at |
 Giants |
Sunday, November 14, 1999 |
3:00PM |
IND 27, NYG 19 |
| Regular Season: Week 11 |
Colts |
at |
 Eagles |
Sunday, November 21, 1999 |
3:00PM |
IND 44, PHI 17 |
| Regular Season: Week 12 |
Jets |
at |
Colts |
Sunday, November 28, 1999 |
3:00PM |
NYJ 6, IND 13 |
| Regular Season: Week 13 |
Colts |
at |
Dolphins |
Sunday, December 5, 1999 |
3:00PM |
IND 37, MIA 34 |
| Regular Season: Week 14 |
Patriots |
at |
Colts |
Sunday, December 12, 1999 |
3:00PM |
NE 15, IND 20 |
| Regular Season: Week 15 |
 Redskins |
at |
Colts |
Sunday, December 19, 1999 |
3:00PM |
WAS 21, IND 24 |
| Regular Season: Week 16 |
Colts |
at |
 Browns |
Sunday, December 26, 1999 |
3:00PM |
IND 29, CLE 28 |
| Regular Season: Week 17 |
Colts |
at |
Bills |
Sunday, January 2, 2000 |
3:00PM |
IND 6, BUF 31 |
| Divisional Playoffs: Week 19 |
 Titans |
at |
Colts |
Sunday, January 16, 2000 |
3:00PM |
TEN 19, IND 16 |