| Regular Season: Week 1 |
 Colts |
at |
 Chiefs |
Sunday, September 3, 2000 |
1:00PM |
IND 27, KC 14 |
| Regular Season: Week 2 |
 Raiders |
at |
Colts |
Sunday, September 10, 2000 |
12:00PM |
OAK 38, IND 31 |
| Regular Season: Week 4 |
 Jaguars |
at |
Colts |
Monday, September 25, 2000 |
9:00PM |
JAC 14, IND 43 |
| Regular Season: Week 5 |
Colts |
at |
 Bills |
Sunday, October 1, 2000 |
1:00PM |
IND 18, BUF 16 |
| Regular Season: Week 6 |
Colts |
at |
 Patriots |
Sunday, October 8, 2000 |
1:00PM |
IND 16, NE 24 |
| Regular Season: Week 7 |
Colts |
at |
 Seahawks |
Sunday, October 15, 2000 |
4:05PM |
IND 37, SEA 24 |
| Regular Season: Week 8 |
Patriots |
at |
Colts |
Sunday, October 22, 2000 |
12:00PM |
NE 23, IND 30 |
| Regular Season: Week 9 |
 Lions |
at |
Colts |
Sunday, October 29, 2000 |
1:00PM |
DET 18, IND 30 |
| Regular Season: Week 10 |
Colts |
at |
 Bears |
Sunday, November 5, 2000 |
1:00PM |
IND 24, CHI 27 |
| Regular Season: Week 11 |
 Jets |
at |
Colts |
Sunday, November 12, 2000 |
8:20PM |
NYJ 15, IND 23 |
| Regular Season: Week 12 |
Colts |
at |
 Packers |
Sunday, November 19, 2000 |
1:00PM |
IND 24, GB 26 |
| Regular Season: Week 13 |
 Dolphins |
at |
Colts |
Sunday, November 26, 2000 |
4:15PM |
MIA 17, IND 14 |
| Regular Season: Week 14 |
Colts |
at |
Jets |
Sunday, December 3, 2000 |
4:15PM |
IND 17, NYJ 27 |
| Regular Season: Week 15 |
Bills |
at |
Colts |
Monday, December 11, 2000 |
9:00PM |
BUF 20, IND 44 |
| Regular Season: Week 16 |
Colts |
at |
Dolphins |
Sunday, December 17, 2000 |
4:15PM |
IND 20, MIA 13 |
| Regular Season: Week 17 |
 Vikings |
at |
Colts |
Sunday, December 24, 2000 |
4:15PM |
MIN 10, IND 31 |
| Wild Card: Week 18 |
Colts |
at |
Dolphins |
Saturday, December 30, 2000 |
12:30PM |
IND 17, MIA 23 |