| Regular Season: Week 1 |
 Bears |
at |
 Colts |
Sunday, September 7, 2008 |
8:15PM |
CHI 29, IND 13 |
| Regular Season: Week 2 |
Colts |
at |
 Vikings |
Sunday, September 14, 2008 |
1:00PM |
IND 18, MIN 15 |
| Regular Season: Week 3 |
 Jaguars |
at |
Colts |
Sunday, September 21, 2008 |
4:15PM |
JAC 23, IND 21 |
| Regular Season: Week 5 |
Colts |
at |
 Texans |
Sunday, October 5, 2008 |
1:00PM |
IND 31, HOU 27 |
| Regular Season: Week 6 |
 Ravens |
at |
Colts |
Sunday, October 12, 2008 |
1:00PM |
BAL 3, IND 31 |
| Regular Season: Week 7 |
Colts |
at |
 Packers |
Sunday, October 19, 2008 |
4:15PM |
IND 14, GB 34 |
| Regular Season: Week 8 |
Colts |
at |
 Titans |
Monday, October 27, 2008 |
8:30PM |
IND 21, TEN 31 |
| Regular Season: Week 9 |
 Patriots |
at |
Colts |
Sunday, November 2, 2008 |
8:15PM |
NE 15, IND 18 |
| Regular Season: Week 10 |
Colts |
at |
 Steelers |
Sunday, November 9, 2008 |
4:15PM |
IND 24, PIT 20 |
| Regular Season: Week 11 |
Texans |
at |
Colts |
Sunday, November 16, 2008 |
1:00PM |
HOU 27, IND 33 |
| Regular Season: Week 12 |
Colts |
at |
 Chargers |
Sunday, November 23, 2008 |
8:15PM |
IND 23, SD 20 |
| Regular Season: Week 13 |
Colts |
at |
 Browns |
Sunday, November 30, 2008 |
1:00PM |
IND 10, CLE 6 |
| Regular Season: Week 14 |
 Bengals |
at |
Colts |
Sunday, December 7, 2008 |
1:00PM |
CIN 3, IND 35 |
| Regular Season: Week 15 |
 Lions |
at |
Colts |
Sunday, December 14, 2008 |
1:00PM |
DET 21, IND 31 |
| Regular Season: Week 16 |
Colts |
at |
Jaguars |
Thursday, December 18, 2008 |
8:15PM |
IND 31, JAC 24 |
| Regular Season: Week 17 |
Titans |
at |
Colts |
Sunday, December 28, 2008 |
1:00PM |
TEN 0, IND 23 |
| Wild Card: Week 18 |
Colts |
at |
Chargers |
Saturday, January 3, 2009 |
8:00PM |
IND 17, SD 23 |