| Regular Season: Week 1 |
 Colts |
at |
 Texans |
Sunday, September 12, 2010 |
1:00PM |
IND 24, HOU 34 |
| Regular Season: Week 2 |
 Giants |
at |
Colts |
Sunday, September 19, 2010 |
8:20PM |
NYG 14, IND 38 |
| Regular Season: Week 3 |
Colts |
at |
 Broncos |
Sunday, September 26, 2010 |
4:15PM |
IND 27, DEN 13 |
| Regular Season: Week 4 |
Colts |
at |
 Jaguars |
Sunday, October 3, 2010 |
4:05PM |
IND 28, JAC 31 |
| Regular Season: Week 5 |
 Chiefs |
at |
Colts |
Sunday, October 10, 2010 |
1:00PM |
KC 9, IND 19 |
| Regular Season: Week 6 |
Colts |
at |
 Redskins |
Sunday, October 17, 2010 |
8:20PM |
IND 27, WAS 24 |
| Regular Season: Week 8 |
Texans |
at |
Colts |
Monday, November 1, 2010 |
8:30PM |
HOU 17, IND 30 |
| Regular Season: Week 9 |
Colts |
at |
 Eagles |
Sunday, November 7, 2010 |
4:15PM |
IND 24, PHI 26 |
| Regular Season: Week 10 |
 Bengals |
at |
Colts |
Sunday, November 14, 2010 |
1:00PM |
CIN 17, IND 23 |
| Regular Season: Week 11 |
Colts |
at |
 Patriots |
Sunday, November 21, 2010 |
4:15PM |
IND 28, NE 31 |
| Regular Season: Week 12 |
 Chargers |
at |
Colts |
Sunday, November 28, 2010 |
8:20PM |
SD 36, IND 14 |
| Regular Season: Week 13 |
 Cowboys |
at |
Colts |
Sunday, December 5, 2010 |
4:15PM |
DAL 38, IND 35 |
| Regular Season: Week 14 |
Colts |
at |
 Titans |
Thursday, December 9, 2010 |
8:20PM |
IND 30, TEN 28 |
| Regular Season: Week 15 |
Jaguars |
at |
Colts |
Sunday, December 19, 2010 |
1:00PM |
JAC 24, IND 34 |
| Regular Season: Week 16 |
Colts |
at |
 Raiders |
Sunday, December 26, 2010 |
4:05PM |
IND 31, OAK 26 |
| Regular Season: Week 17 |
Titans |
at |
Colts |
Sunday, January 2, 2011 |
4:15PM |
TEN 20, IND 23 |
| Wild Card: Week 18 |
 Jets |
at |
Colts |
Saturday, January 8, 2011 |
8:00PM |
NYJ 17, IND 16 |