| Regular Season: Week 1 |
 Lions |
at |
 Colts |
Sunday, September 11, 2016 |
4:25PM |
DET 39, IND 35 |
| Regular Season: Week 2 |
Colts |
at |
 Broncos |
Sunday, September 18, 2016 |
4:25PM |
IND 20, DEN 34 |
| Regular Season: Week 3 |
 Chargers |
at |
Colts |
Sunday, September 25, 2016 |
4:25PM |
SD 22, IND 26 |
| Regular Season: Week 4 |
Colts |
at |
 Jaguars |
Sunday, October 2, 2016 |
9:30PM |
IND 27, JAX 30 |
| Regular Season: Week 5 |
 Bears |
at |
Colts |
Sunday, October 9, 2016 |
1:00PM |
CHI 23, IND 29 |
| Regular Season: Week 6 |
Colts |
at |
 Texans |
Sunday, October 16, 2016 |
8:30PM |
IND 23, HOU 26 |
| Regular Season: Week 7 |
Colts |
at |
 Titans |
Sunday, October 23, 2016 |
1:00PM |
IND 34, TEN 26 |
| Regular Season: Week 8 |
 Chiefs |
at |
Colts |
Sunday, October 30, 2016 |
1:00PM |
KC 30, IND 14 |
| Regular Season: Week 9 |
Colts |
at |
 Packers |
Sunday, November 6, 2016 |
4:25PM |
IND 31, GB 26 |
| Regular Season: Week 11 |
Titans |
at |
Colts |
Sunday, November 20, 2016 |
1:00PM |
TEN 17, IND 24 |
| Regular Season: Week 12 |
 Steelers |
at |
Colts |
Thursday, November 24, 2016 |
8:30PM |
PIT 28, IND 7 |
| Regular Season: Week 13 |
Colts |
at |
 Jets |
Monday, December 5, 2016 |
8:30PM |
IND 41, NYJ 10 |
| Regular Season: Week 14 |
Texans |
at |
Colts |
Sunday, December 11, 2016 |
1:00PM |
HOU 22, IND 17 |
| Regular Season: Week 15 |
Colts |
at |
 Vikings |
Sunday, December 18, 2016 |
1:00PM |
IND 34, MIN 6 |
| Regular Season: Week 16 |
Colts |
at |
 Raiders |
Saturday, December 24, 2016 |
4:05PM |
IND 25, OAK 33 |
| Regular Season: Week 17 |
Jaguars |
at |
Colts |
Sunday, January 1, 2017 |
1:00PM |
JAX 20, IND 24 |