| Regular Season: Week 1 |
 Colts |
at |
 Rams |
Sunday, September 10, 2017 |
4:05PM |
IND 9, LA 46 |
| Regular Season: Week 2 |
 Cardinals |
at |
Colts |
Sunday, September 17, 2017 |
1:00PM |
ARI 16, IND 13 |
| Regular Season: Week 3 |
 Browns |
at |
Colts |
Sunday, September 24, 2017 |
1:00PM |
CLE 28, IND 31 |
| Regular Season: Week 4 |
Colts |
at |
 Seahawks |
Sunday, October 1, 2017 |
8:30PM |
IND 18, SEA 46 |
| Regular Season: Week 5 |
 49ers |
at |
Colts |
Sunday, October 8, 2017 |
1:00PM |
SF 23, IND 26 |
| Regular Season: Week 6 |
Colts |
at |
 Titans |
Monday, October 16, 2017 |
8:30PM |
IND 22, TEN 36 |
| Regular Season: Week 7 |
 Jaguars |
at |
Colts |
Sunday, October 22, 2017 |
1:00PM |
JAX 27, IND 0 |
| Regular Season: Week 8 |
Colts |
at |
 Bengals |
Sunday, October 29, 2017 |
1:00PM |
IND 23, CIN 24 |
| Regular Season: Week 9 |
Colts |
at |
 Texans |
Sunday, November 5, 2017 |
1:00PM |
IND 20, HOU 14 |
| Regular Season: Week 10 |
 Steelers |
at |
Colts |
Sunday, November 12, 2017 |
1:00PM |
PIT 20, IND 17 |
| Regular Season: Week 12 |
Titans |
at |
Colts |
Sunday, November 26, 2017 |
1:00PM |
TEN 20, IND 16 |
| Regular Season: Week 13 |
Colts |
at |
Jaguars |
Sunday, December 3, 2017 |
1:00PM |
IND 10, JAX 30 |
| Regular Season: Week 14 |
Colts |
at |
 Bills |
Sunday, December 10, 2017 |
1:00PM |
IND 7, BUF 13 |
| Regular Season: Week 15 |
 Broncos |
at |
Colts |
Thursday, December 14, 2017 |
8:25PM |
DEN 25, IND 13 |
| Regular Season: Week 16 |
Colts |
at |
 Ravens |
Saturday, December 23, 2017 |
4:30PM |
IND 16, BAL 23 |
| Regular Season: Week 17 |
Texans |
at |
Colts |
Sunday, December 31, 2017 |
1:00PM |
HOU 13, IND 22 |