| Regular Season: Week 1 |
 Colts |
at |
 Jaguars |
Sunday, September 13, 2020 |
1:00PM |
IND 20, JAX 27 |
| Regular Season: Week 2 |
 Vikings |
at |
Colts |
Sunday, September 20, 2020 |
1:00PM |
MIN 11, IND 28 |
| Regular Season: Week 3 |
 Jets |
at |
Colts |
Sunday, September 27, 2020 |
4:05PM |
NYJ 7, IND 36 |
| Regular Season: Week 4 |
Colts |
at |
 Bears |
Sunday, October 4, 2020 |
4:25PM |
IND 19, CHI 11 |
| Regular Season: Week 5 |
Colts |
at |
 Browns |
Sunday, October 11, 2020 |
4:25PM |
IND 23, CLE 32 |
| Regular Season: Week 6 |
 Bengals |
at |
Colts |
Sunday, October 18, 2020 |
1:00PM |
CIN 27, IND 31 |
| Regular Season: Week 8 |
Colts |
at |
 Lions |
Sunday, November 1, 2020 |
1:00PM |
IND 41, DET 21 |
| Regular Season: Week 9 |
 Ravens |
at |
Colts |
Sunday, November 8, 2020 |
1:00PM |
BAL 24, IND 10 |
| Regular Season: Week 10 |
Colts |
at |
 Titans |
Thursday, November 12, 2020 |
8:20PM |
IND 34, TEN 17 |
| Regular Season: Week 11 |
 Packers |
at |
Colts |
Sunday, November 22, 2020 |
4:25PM |
GB 31, IND 34 |
| Regular Season: Week 12 |
Titans |
at |
Colts |
Sunday, November 29, 2020 |
1:00PM |
TEN 45, IND 26 |
| Regular Season: Week 13 |
Colts |
at |
 Texans |
Sunday, December 6, 2020 |
1:00PM |
IND 26, HOU 20 |
| Regular Season: Week 14 |
Colts |
at |
 Raiders |
Sunday, December 13, 2020 |
4:05PM |
IND 44, LV 27 |
| Regular Season: Week 15 |
Texans |
at |
Colts |
Sunday, December 20, 2020 |
1:00PM |
HOU 20, IND 27 |
| Regular Season: Week 16 |
Colts |
at |
 Steelers |
Sunday, December 27, 2020 |
1:00PM |
IND 24, PIT 28 |
| Regular Season: Week 17 |
Jaguars |
at |
Colts |
Sunday, January 3, 2021 |
4:25PM |
JAX 14, IND 28 |
| Wild Card: Week 18 |
Colts |
at |
 Bills |
Saturday, January 9, 2021 |
1:05PM |
IND 24, BUF 27 |