| Regular Season: Week 1 |
 Dolphins |
at |
 Bills |
Sunday, September 7, 1980 |
3:00PM |
MIA 7, BUF 17 |
| Regular Season: Week 2 |
 Bengals |
at |
Dolphins |
Sunday, September 14, 1980 |
3:00PM |
CIN 16, MIA 17 |
| Regular Season: Week 3 |
Dolphins |
at |
 Falcons |
Sunday, September 21, 1980 |
3:00PM |
MIA 20, ATL 17 |
| Regular Season: Week 4 |
 Saints |
at |
Dolphins |
Sunday, September 28, 1980 |
3:00PM |
NO 16, MIA 21 |
| Regular Season: Week 5 |
 Colts |
at |
Dolphins |
Sunday, October 5, 1980 |
3:00PM |
BAL 30, MIA 17 |
| Regular Season: Week 6 |
Dolphins |
at |
 Patriots |
Sunday, October 12, 1980 |
3:00PM |
MIA 0, NE 34 |
| Regular Season: Week 7 |
Bills |
at |
Dolphins |
Sunday, October 19, 1980 |
3:00PM |
BUF 14, MIA 17 |
| Regular Season: Week 8 |
Dolphins |
at |
 Jets |
Monday, October 27, 1980 |
3:00PM |
MIA 14, NYJ 17 |
| Regular Season: Week 9 |
Dolphins |
at |
 Raiders |
Sunday, November 2, 1980 |
3:00PM |
MIA 10, OAK 16 |
| Regular Season: Week 10 |
Dolphins |
at |
 Rams |
Sunday, November 9, 1980 |
3:00PM |
MIA 35, LA 14 |
| Regular Season: Week 11 |
 49ers |
at |
Dolphins |
Sunday, November 16, 1980 |
3:00PM |
SF 13, MIA 17 |
| Regular Season: Week 12 |
 Chargers |
at |
Dolphins |
Thursday, November 20, 1980 |
3:00PM |
SD 27, MIA 24 |
| Regular Season: Week 13 |
Dolphins |
at |
 Steelers |
Sunday, November 30, 1980 |
3:00PM |
MIA 10, PIT 23 |
| Regular Season: Week 14 |
Patriots |
at |
Dolphins |
Monday, December 8, 1980 |
3:00PM |
NE 13, MIA 16 |
| Regular Season: Week 15 |
Dolphins |
at |
Colts |
Sunday, December 14, 1980 |
3:00PM |
MIA 24, BAL 14 |
| Regular Season: Week 16 |
Jets |
at |
Dolphins |
Saturday, December 20, 1980 |
3:00PM |
NYJ 24, MIA 17 |