| Regular Season: Week 1 |
 Eagles |
at |
 Giants |
Sunday, September 6, 1981 |
3:00PM |
PHI 24, NYG 10 |
| Regular Season: Week 2 |
 Patriots |
at |
Eagles |
Sunday, September 13, 1981 |
3:00PM |
NE 3, PHI 13 |
| Regular Season: Week 3 |
Eagles |
at |
 Bills |
Thursday, September 17, 1981 |
3:00PM |
PHI 20, BUF 14 |
| Regular Season: Week 4 |
 Redskins |
at |
Eagles |
Sunday, September 27, 1981 |
3:00PM |
WAS 13, PHI 36 |
| Regular Season: Week 5 |
 Falcons |
at |
Eagles |
Monday, October 5, 1981 |
3:00PM |
ATL 13, PHI 16 |
| Regular Season: Week 6 |
Eagles |
at |
 Saints |
Sunday, October 11, 1981 |
3:00PM |
PHI 31, NO 14 |
| Regular Season: Week 7 |
Eagles |
at |
 Vikings |
Sunday, October 18, 1981 |
3:00PM |
PHI 23, MIN 35 |
| Regular Season: Week 8 |
 Buccaneers |
at |
Eagles |
Sunday, October 25, 1981 |
2:00PM |
TB 10, PHI 20 |
| Regular Season: Week 9 |
 Cowboys |
at |
Eagles |
Sunday, November 1, 1981 |
3:00PM |
DAL 17, PHI 14 |
| Regular Season: Week 10 |
Eagles |
at |
 Cardinals |
Sunday, November 8, 1981 |
3:00PM |
PHI 52, STL 10 |
| Regular Season: Week 11 |
 Colts |
at |
Eagles |
Sunday, November 15, 1981 |
3:00PM |
BAL 13, PHI 38 |
| Regular Season: Week 12 |
Giants |
at |
Eagles |
Sunday, November 22, 1981 |
3:00PM |
NYG 20, PHI 10 |
| Regular Season: Week 13 |
Eagles |
at |
 Dolphins |
Monday, November 30, 1981 |
3:00PM |
PHI 10, MIA 13 |
| Regular Season: Week 14 |
Eagles |
at |
Redskins |
Sunday, December 6, 1981 |
3:00PM |
PHI 13, WAS 15 |
| Regular Season: Week 15 |
Eagles |
at |
Cowboys |
Sunday, December 13, 1981 |
3:00PM |
PHI 10, DAL 21 |
| Regular Season: Week 16 |
Cardinals |
at |
Eagles |
Sunday, December 20, 1981 |
3:00PM |
STL 0, PHI 38 |
| Wild Card: Week 17 |
Giants |
at |
Eagles |
Sunday, December 27, 1981 |
3:00PM |
NYG 27, PHI 21 |