| Regular Season: Week 1 |
 Giants |
at |
 Buccaneers |
Saturday, September 2, 1978 |
3:00PM |
NYG 19, TB 13 |
| Regular Season: Week 2 |
 Cowboys |
at |
Giants |
Sunday, September 10, 1978 |
3:00PM |
DAL 34, NYG 24 |
| Regular Season: Week 3 |
 Chiefs |
at |
Giants |
Sunday, September 17, 1978 |
3:00PM |
KC 10, NYG 26 |
| Regular Season: Week 4 |
 49ers |
at |
Giants |
Sunday, September 24, 1978 |
3:00PM |
SF 10, NYG 27 |
| Regular Season: Week 5 |
Giants |
at |
 Falcons |
Sunday, October 1, 1978 |
3:00PM |
NYG 20, ATL 23 |
| Regular Season: Week 6 |
Giants |
at |
Cowboys |
Sunday, October 8, 1978 |
3:00PM |
NYG 3, DAL 24 |
| Regular Season: Week 7 |
Buccaneers |
at |
Giants |
Sunday, October 15, 1978 |
3:00PM |
TB 14, NYG 17 |
| Regular Season: Week 8 |
 Redskins |
at |
Giants |
Sunday, October 22, 1978 |
3:00PM |
WAS 6, NYG 17 |
| Regular Season: Week 9 |
Giants |
at |
 Saints |
Sunday, October 29, 1978 |
2:00PM |
NYG 17, NO 28 |
| Regular Season: Week 10 |
Giants |
at |
 Cardinals |
Sunday, November 5, 1978 |
3:00PM |
NYG 10, STL 20 |
| Regular Season: Week 11 |
Giants |
at |
Redskins |
Sunday, November 12, 1978 |
3:00PM |
NYG 13, WAS 16 |
| Regular Season: Week 12 |
 Eagles |
at |
Giants |
Sunday, November 19, 1978 |
3:00PM |
PHI 19, NYG 17 |
| Regular Season: Week 13 |
Giants |
at |
 Bills |
Sunday, November 26, 1978 |
3:00PM |
NYG 17, BUF 41 |
| Regular Season: Week 14 |
 Rams |
at |
Giants |
Sunday, December 3, 1978 |
3:00PM |
LA 20, NYG 17 |
| Regular Season: Week 15 |
Cardinals |
at |
Giants |
Sunday, December 10, 1978 |
3:00PM |
STL 0, NYG 17 |
| Regular Season: Week 16 |
Giants |
at |
Eagles |
Sunday, December 17, 1978 |
3:00PM |
NYG 3, PHI 20 |