| Regular Season: Week 1 |
 Giants |
at |
 Cardinals |
Sunday, September 7, 1980 |
3:00PM |
NYG 41, STL 35 |
| Regular Season: Week 2 |
 Redskins |
at |
Giants |
Sunday, September 14, 1980 |
3:00PM |
WAS 23, NYG 21 |
| Regular Season: Week 3 |
Giants |
at |
 Eagles |
Monday, September 22, 1980 |
3:00PM |
NYG 3, PHI 35 |
| Regular Season: Week 4 |
 Rams |
at |
Giants |
Sunday, September 28, 1980 |
3:00PM |
LA 28, NYG 7 |
| Regular Season: Week 5 |
Giants |
at |
 Cowboys |
Sunday, October 5, 1980 |
3:00PM |
NYG 3, DAL 24 |
| Regular Season: Week 6 |
Eagles |
at |
Giants |
Sunday, October 12, 1980 |
3:00PM |
PHI 31, NYG 16 |
| Regular Season: Week 7 |
Giants |
at |
 Chargers |
Sunday, October 19, 1980 |
3:00PM |
NYG 7, SD 44 |
| Regular Season: Week 8 |
 Broncos |
at |
Giants |
Sunday, October 26, 1980 |
2:00PM |
DEN 14, NYG 9 |
| Regular Season: Week 9 |
Giants |
at |
 Buccaneers |
Sunday, November 2, 1980 |
3:00PM |
NYG 13, TB 30 |
| Regular Season: Week 10 |
Cowboys |
at |
Giants |
Sunday, November 9, 1980 |
3:00PM |
DAL 35, NYG 38 |
| Regular Season: Week 11 |
 Packers |
at |
Giants |
Sunday, November 16, 1980 |
3:00PM |
GB 21, NYG 27 |
| Regular Season: Week 12 |
Giants |
at |
 49ers |
Sunday, November 23, 1980 |
3:00PM |
NYG 0, SF 12 |
| Regular Season: Week 13 |
Cardinals |
at |
Giants |
Sunday, November 30, 1980 |
3:00PM |
STL 23, NYG 7 |
| Regular Season: Week 14 |
Giants |
at |
 Seahawks |
Sunday, December 7, 1980 |
3:00PM |
NYG 27, SEA 21 |
| Regular Season: Week 15 |
Giants |
at |
Redskins |
Saturday, December 13, 1980 |
3:00PM |
NYG 13, WAS 16 |
| Regular Season: Week 16 |
 Raiders |
at |
Giants |
Sunday, December 21, 1980 |
3:00PM |
OAK 33, NYG 17 |