| Regular Season: Week 1 |
 Redskins |
at |
 Giants |
Monday, September 5, 1988 |
3:00PM |
WAS 20, NYG 27 |
| Regular Season: Week 2 |
 49ers |
at |
Giants |
Sunday, September 11, 1988 |
3:00PM |
SF 20, NYG 17 |
| Regular Season: Week 3 |
Giants |
at |
 Cowboys |
Sunday, September 18, 1988 |
3:00PM |
NYG 12, DAL 10 |
| Regular Season: Week 4 |
 Rams |
at |
Giants |
Sunday, September 25, 1988 |
3:00PM |
RAM 45, NYG 31 |
| Regular Season: Week 5 |
Giants |
at |
Redskins |
Sunday, October 2, 1988 |
3:00PM |
NYG 24, WAS 23 |
| Regular Season: Week 6 |
Giants |
at |
 Eagles |
Monday, October 10, 1988 |
3:00PM |
NYG 13, PHI 24 |
| Regular Season: Week 7 |
 Lions |
at |
Giants |
Sunday, October 16, 1988 |
3:00PM |
DET 10, NYG 30 |
| Regular Season: Week 8 |
Giants |
at |
 Falcons |
Sunday, October 23, 1988 |
3:00PM |
NYG 23, ATL 16 |
| Regular Season: Week 9 |
Giants |
at |
Lions |
Sunday, October 30, 1988 |
2:00PM |
NYG 13, DET 10 |
| Regular Season: Week 10 |
Cowboys |
at |
Giants |
Sunday, November 6, 1988 |
3:00PM |
DAL 21, NYG 29 |
| Regular Season: Week 11 |
Giants |
at |
 Cardinals |
Sunday, November 13, 1988 |
3:00PM |
NYG 17, PHO 24 |
| Regular Season: Week 12 |
Eagles |
at |
Giants |
Sunday, November 20, 1988 |
3:00PM |
PHI 23, NYG 17 |
| Regular Season: Week 13 |
Giants |
at |
 Saints |
Sunday, November 27, 1988 |
3:00PM |
NYG 13, NO 12 |
| Regular Season: Week 14 |
Cardinals |
at |
Giants |
Sunday, December 4, 1988 |
3:00PM |
PHO 7, NYG 44 |
| Regular Season: Week 15 |
 Chiefs |
at |
Giants |
Sunday, December 11, 1988 |
3:00PM |
KC 12, NYG 28 |
| Regular Season: Week 16 |
Giants |
at |
 Jets |
Sunday, December 18, 1988 |
3:00PM |
NYG 21, NYJ 27 |