| Regular Season: Week 1 |
 Giants |
at |
 Buccaneers |
Sunday, September 12, 1999 |
3:00PM |
NYG 17, TB 13 |
| Regular Season: Week 2 |
 Redskins |
at |
Giants |
Sunday, September 19, 1999 |
3:00PM |
WAS 50, NYG 21 |
| Regular Season: Week 3 |
Giants |
at |
 Patriots |
Sunday, September 26, 1999 |
3:00PM |
NYG 14, NE 16 |
| Regular Season: Week 4 |
 Eagles |
at |
Giants |
Sunday, October 3, 1999 |
3:00PM |
PHI 15, NYG 16 |
| Regular Season: Week 5 |
Giants |
at |
 Cardinals |
Sunday, October 10, 1999 |
3:00PM |
NYG 3, ARI 14 |
| Regular Season: Week 6 |
 Cowboys |
at |
Giants |
Monday, October 18, 1999 |
3:00PM |
DAL 10, NYG 13 |
| Regular Season: Week 7 |
 Saints |
at |
Giants |
Sunday, October 24, 1999 |
3:00PM |
NO 3, NYG 31 |
| Regular Season: Week 8 |
Giants |
at |
Eagles |
Sunday, October 31, 1999 |
2:00PM |
NYG 23, PHI 17 |
| Regular Season: Week 10 |
 Colts |
at |
Giants |
Sunday, November 14, 1999 |
3:00PM |
IND 27, NYG 19 |
| Regular Season: Week 11 |
Giants |
at |
Redskins |
Sunday, November 21, 1999 |
3:00PM |
NYG 13, WAS 23 |
| Regular Season: Week 12 |
Cardinals |
at |
Giants |
Sunday, November 28, 1999 |
3:00PM |
ARI 34, NYG 24 |
| Regular Season: Week 13 |
 Jets |
at |
Giants |
Sunday, December 5, 1999 |
3:00PM |
NYJ 28, NYG 41 |
| Regular Season: Week 14 |
Giants |
at |
 Bills |
Sunday, December 12, 1999 |
3:00PM |
NYG 19, BUF 17 |
| Regular Season: Week 15 |
Giants |
at |
 Rams |
Sunday, December 19, 1999 |
3:00PM |
NYG 10, STL 31 |
| Regular Season: Week 16 |
 Vikings |
at |
Giants |
Sunday, December 26, 1999 |
3:00PM |
MIN 34, NYG 17 |
| Regular Season: Week 17 |
Giants |
at |
Cowboys |
Sunday, January 2, 2000 |
3:00PM |
NYG 18, DAL 26 |