| Regular Season: Week 1 |
 Panthers |
at |
 Giants |
Sunday, September 12, 2010 |
1:00PM |
CAR 18, NYG 31 |
| Regular Season: Week 2 |
Giants |
at |
 Colts |
Sunday, September 19, 2010 |
8:20PM |
NYG 14, IND 38 |
| Regular Season: Week 3 |
 Titans |
at |
Giants |
Sunday, September 26, 2010 |
1:00PM |
TEN 29, NYG 10 |
| Regular Season: Week 4 |
 Bears |
at |
Giants |
Sunday, October 3, 2010 |
8:20PM |
CHI 3, NYG 17 |
| Regular Season: Week 5 |
Giants |
at |
 Texans |
Sunday, October 10, 2010 |
1:00PM |
NYG 34, HOU 10 |
| Regular Season: Week 6 |
 Lions |
at |
Giants |
Sunday, October 17, 2010 |
1:00PM |
DET 20, NYG 28 |
| Regular Season: Week 7 |
Giants |
at |
 Cowboys |
Monday, October 25, 2010 |
8:30PM |
NYG 41, DAL 35 |
| Regular Season: Week 9 |
Giants |
at |
 Seahawks |
Sunday, November 7, 2010 |
4:05PM |
NYG 41, SEA 7 |
| Regular Season: Week 10 |
Cowboys |
at |
Giants |
Sunday, November 14, 2010 |
4:15PM |
DAL 33, NYG 20 |
| Regular Season: Week 11 |
Giants |
at |
 Eagles |
Sunday, November 21, 2010 |
8:20PM |
NYG 17, PHI 27 |
| Regular Season: Week 12 |
 Jaguars |
at |
Giants |
Sunday, November 28, 2010 |
1:00PM |
JAC 20, NYG 24 |
| Regular Season: Week 13 |
 Redskins |
at |
Giants |
Sunday, December 5, 2010 |
1:00PM |
WAS 7, NYG 31 |
| Regular Season: Week 14 |
Giants |
at |
 Vikings |
Monday, December 13, 2010 |
7:20PM |
NYG 21, MIN 3 |
| Regular Season: Week 15 |
Eagles |
at |
Giants |
Sunday, December 19, 2010 |
1:00PM |
PHI 38, NYG 31 |
| Regular Season: Week 16 |
Giants |
at |
 Packers |
Sunday, December 26, 2010 |
4:15PM |
NYG 17, GB 45 |
| Regular Season: Week 17 |
Giants |
at |
Redskins |
Sunday, January 2, 2011 |
4:15PM |
NYG 17, WAS 14 |