| Regular Season: Week 1 |
 Broncos |
at |
 Giants |
Sunday, September 12, 2021 |
4:25PM |
DEN 27, NYG 13 |
| Regular Season: Week 2 |
Giants |
at |
 Washington |
Thursday, September 16, 2021 |
8:20PM |
NYG 29, WSH 30 |
| Regular Season: Week 3 |
 Falcons |
at |
Giants |
Sunday, September 26, 2021 |
1:00PM |
ATL 17, NYG 14 |
| Regular Season: Week 4 |
Giants |
at |
 Saints |
Sunday, October 3, 2021 |
1:00PM |
NYG 27, NO 21 |
| Regular Season: Week 5 |
Giants |
at |
 Cowboys |
Sunday, October 10, 2021 |
4:25PM |
NYG 20, DAL 44 |
| Regular Season: Week 6 |
 Rams |
at |
Giants |
Sunday, October 17, 2021 |
1:00PM |
LAR 38, NYG 11 |
| Regular Season: Week 7 |
 Panthers |
at |
Giants |
Sunday, October 24, 2021 |
1:00PM |
CAR 3, NYG 25 |
| Regular Season: Week 8 |
Giants |
at |
 Chiefs |
Monday, November 1, 2021 |
8:15PM |
NYG 17, KC 20 |
| Regular Season: Week 9 |
 Raiders |
at |
Giants |
Sunday, November 7, 2021 |
1:00PM |
LV 16, NYG 23 |
| Regular Season: Week 11 |
Giants |
at |
 Buccaneers |
Monday, November 22, 2021 |
8:15PM |
NYG 10, TB 30 |
| Regular Season: Week 12 |
 Eagles |
at |
Giants |
Sunday, November 28, 2021 |
1:00PM |
PHI 7, NYG 13 |
| Regular Season: Week 13 |
Giants |
at |
 Dolphins |
Sunday, December 5, 2021 |
1:00PM |
NYG 9, MIA 20 |
| Regular Season: Week 14 |
Giants |
at |
 Chargers |
Sunday, December 12, 2021 |
4:05PM |
NYG 21, LAC 37 |
| Regular Season: Week 15 |
Cowboys |
at |
Giants |
Sunday, December 19, 2021 |
1:00PM |
DAL 21, NYG 6 |
| Regular Season: Week 16 |
Giants |
at |
Eagles |
Sunday, December 26, 2021 |
1:00PM |
NYG 10, PHI 34 |
| Regular Season: Week 17 |
Giants |
at |
 Bears |
Sunday, January 2, 2022 |
1:00PM |
NYG 3, CHI 29 |
| Regular Season: Week 18 |
Washington |
at |
Giants |
Sunday, January 9, 2022 |
1:00PM |
WSH 22, NYG 7 |