| Regular Season: Week 1 |
 Jaguars |
at |
 Texans |
Sunday, September 12, 2021 |
1:00PM |
JAX 21, HOU 37 |
| Regular Season: Week 2 |
 Broncos |
at |
Jaguars |
Sunday, September 19, 2021 |
1:00PM |
DEN 23, JAX 13 |
| Regular Season: Week 3 |
 Cardinals |
at |
Jaguars |
Sunday, September 26, 2021 |
1:00PM |
ARI 31, JAX 19 |
| Regular Season: Week 4 |
Jaguars |
at |
 Bengals |
Thursday, September 30, 2021 |
8:20PM |
JAX 21, CIN 24 |
| Regular Season: Week 5 |
 Titans |
at |
Jaguars |
Sunday, October 10, 2021 |
1:00PM |
TEN 37, JAX 19 |
| Regular Season: Week 6 |
 Dolphins |
at |
Jaguars |
Sunday, October 17, 2021 |
9:30AM |
MIA 20, JAX 23 |
| Regular Season: Week 8 |
Jaguars |
at |
 Seahawks |
Sunday, October 31, 2021 |
4:05PM |
JAX 7, SEA 31 |
| Regular Season: Week 9 |
 Bills |
at |
Jaguars |
Sunday, November 7, 2021 |
1:00PM |
BUF 6, JAX 9 |
| Regular Season: Week 10 |
Jaguars |
at |
 Colts |
Sunday, November 14, 2021 |
1:00PM |
JAX 17, IND 23 |
| Regular Season: Week 11 |
 49ers |
at |
Jaguars |
Sunday, November 21, 2021 |
1:00PM |
SF 30, JAX 10 |
| Regular Season: Week 12 |
 Falcons |
at |
Jaguars |
Sunday, November 28, 2021 |
1:00PM |
ATL 21, JAX 14 |
| Regular Season: Week 13 |
Jaguars |
at |
 Rams |
Sunday, December 5, 2021 |
4:25PM |
JAX 7, LAR 37 |
| Regular Season: Week 14 |
Jaguars |
at |
Titans |
Sunday, December 12, 2021 |
1:00PM |
JAX 0, TEN 20 |
| Regular Season: Week 15 |
Texans |
at |
Jaguars |
Sunday, December 19, 2021 |
1:00PM |
HOU 30, JAX 16 |
| Regular Season: Week 16 |
Jaguars |
at |
 Jets |
Sunday, December 26, 2021 |
1:00PM |
JAX 21, NYJ 26 |
| Regular Season: Week 17 |
Jaguars |
at |
 Patriots |
Sunday, January 2, 2022 |
1:00PM |
JAX 10, NE 50 |
| Regular Season: Week 18 |
Colts |
at |
Jaguars |
Sunday, January 9, 2022 |
1:00PM |
IND 11, JAX 26 |