| Regular Season: Week 1 |
 Lions |
at |
 Cowboys |
Sunday, September 15, 1968 |
3:00PM |
DET 13, DAL 59 |
| Regular Season: Week 2 |
 Bears |
at |
Lions |
Sunday, September 22, 1968 |
3:00PM |
CHI 0, DET 42 |
| Regular Season: Week 3 |
Lions |
at |
 Packers |
Sunday, September 29, 1968 |
3:00PM |
DET 23, GB 17 |
| Regular Season: Week 4 |
Lions |
at |
 Vikings |
Sunday, October 6, 1968 |
3:00PM |
DET 10, MIN 24 |
| Regular Season: Week 5 |
Lions |
at |
Bears |
Sunday, October 13, 1968 |
3:00PM |
DET 28, CHI 10 |
| Regular Season: Week 6 |
Packers |
at |
Lions |
Sunday, October 20, 1968 |
3:00PM |
GB 14, DET 14 |
| Regular Season: Week 7 |
 49ers |
at |
Lions |
Sunday, October 27, 1968 |
2:00PM |
SF 14, DET 7 |
| Regular Season: Week 8 |
Lions |
at |
 Rams |
Sunday, November 3, 1968 |
3:00PM |
DET 7, LA 10 |
| Regular Season: Week 9 |
 Colts |
at |
Lions |
Sunday, November 10, 1968 |
3:00PM |
BAL 27, DET 10 |
| Regular Season: Week 10 |
Vikings |
at |
Lions |
Sunday, November 17, 1968 |
3:00PM |
MIN 13, DET 6 |
| Regular Season: Week 11 |
 Saints |
at |
Lions |
Sunday, November 24, 1968 |
3:00PM |
NO 20, DET 20 |
| Regular Season: Week 12 |
 Eagles |
at |
Lions |
Thursday, November 28, 1968 |
3:00PM |
PHI 12, DET 0 |
| Regular Season: Week 13 |
Lions |
at |
 Falcons |
Sunday, December 8, 1968 |
3:00PM |
DET 24, ATL 7 |
| Regular Season: Week 14 |
Lions |
at |
 Redskins |
Sunday, December 15, 1968 |
3:00PM |
DET 3, WAS 14 |