| Regular Season: Week 1 |
 Packers |
at |
 Lions |
Sunday, September 3, 1978 |
3:00PM |
GB 13, DET 7 |
| Regular Season: Week 2 |
Lions |
at |
 Buccaneers |
Saturday, September 9, 1978 |
3:00PM |
DET 15, TB 7 |
| Regular Season: Week 3 |
 Bears |
at |
Lions |
Sunday, September 17, 1978 |
3:00PM |
CHI 19, DET 0 |
| Regular Season: Week 4 |
Lions |
at |
 Seahawks |
Sunday, September 24, 1978 |
3:00PM |
DET 16, SEA 28 |
| Regular Season: Week 5 |
Lions |
at |
Packers |
Sunday, October 1, 1978 |
3:00PM |
DET 14, GB 35 |
| Regular Season: Week 6 |
 Redskins |
at |
Lions |
Sunday, October 8, 1978 |
3:00PM |
WAS 21, DET 19 |
| Regular Season: Week 7 |
Lions |
at |
 Falcons |
Sunday, October 15, 1978 |
3:00PM |
DET 0, ATL 14 |
| Regular Season: Week 8 |
 Chargers |
at |
Lions |
Sunday, October 22, 1978 |
3:00PM |
SD 14, DET 31 |
| Regular Season: Week 9 |
Lions |
at |
Bears |
Sunday, October 29, 1978 |
2:00PM |
DET 21, CHI 17 |
| Regular Season: Week 10 |
Lions |
at |
 Vikings |
Sunday, November 5, 1978 |
3:00PM |
DET 7, MIN 17 |
| Regular Season: Week 11 |
Buccaneers |
at |
Lions |
Sunday, November 12, 1978 |
3:00PM |
TB 23, DET 34 |
| Regular Season: Week 12 |
Lions |
at |
 Raiders |
Sunday, November 19, 1978 |
3:00PM |
DET 17, OAK 29 |
| Regular Season: Week 13 |
 Broncos |
at |
Lions |
Thursday, November 23, 1978 |
3:00PM |
DEN 14, DET 17 |
| Regular Season: Week 14 |
Lions |
at |
 Cardinals |
Sunday, December 3, 1978 |
3:00PM |
DET 14, STL 21 |
| Regular Season: Week 15 |
Vikings |
at |
Lions |
Saturday, December 9, 1978 |
3:00PM |
MIN 14, DET 45 |
| Regular Season: Week 16 |
 49ers |
at |
Lions |
Sunday, December 17, 1978 |
3:00PM |
SF 14, DET 33 |