| Regular Season: Week 1 |
 Lions |
at |
 Falcons |
Sunday, September 8, 1985 |
3:00PM |
DET 28, ATL 27 |
| Regular Season: Week 2 |
 Cowboys |
at |
Lions |
Sunday, September 15, 1985 |
3:00PM |
DAL 21, DET 26 |
| Regular Season: Week 3 |
Lions |
at |
 Colts |
Sunday, September 22, 1985 |
3:00PM |
DET 6, IND 14 |
| Regular Season: Week 4 |
 Buccaneers |
at |
Lions |
Sunday, September 29, 1985 |
3:00PM |
TB 9, DET 30 |
| Regular Season: Week 5 |
Lions |
at |
 Packers |
Sunday, October 6, 1985 |
3:00PM |
DET 10, GB 43 |
| Regular Season: Week 6 |
Lions |
at |
 Redskins |
Sunday, October 13, 1985 |
3:00PM |
DET 3, WAS 24 |
| Regular Season: Week 7 |
 49ers |
at |
Lions |
Sunday, October 20, 1985 |
3:00PM |
SF 21, DET 23 |
| Regular Season: Week 8 |
 Dolphins |
at |
Lions |
Sunday, October 27, 1985 |
2:00PM |
MIA 21, DET 31 |
| Regular Season: Week 9 |
Lions |
at |
 Vikings |
Sunday, November 3, 1985 |
3:00PM |
DET 13, MIN 16 |
| Regular Season: Week 10 |
Lions |
at |
 Bears |
Sunday, November 10, 1985 |
3:00PM |
DET 3, CHI 24 |
| Regular Season: Week 11 |
Vikings |
at |
Lions |
Sunday, November 17, 1985 |
3:00PM |
MIN 21, DET 41 |
| Regular Season: Week 12 |
Lions |
at |
Buccaneers |
Sunday, November 24, 1985 |
3:00PM |
DET 16, TB 19 |
| Regular Season: Week 13 |
 Jets |
at |
Lions |
Thursday, November 28, 1985 |
3:00PM |
NYJ 20, DET 31 |
| Regular Season: Week 14 |
Lions |
at |
 Patriots |
Sunday, December 8, 1985 |
3:00PM |
DET 6, NE 23 |
| Regular Season: Week 15 |
Packers |
at |
Lions |
Sunday, December 15, 1985 |
3:00PM |
GB 26, DET 23 |
| Regular Season: Week 16 |
Bears |
at |
Lions |
Sunday, December 22, 1985 |
3:00PM |
CHI 37, DET 17 |