| Regular Season: Week 1 |
 Falcons |
at |
 Lions |
Sunday, September 4, 1988 |
3:00PM |
ATL 17, DET 31 |
| Regular Season: Week 2 |
Lions |
at |
 Rams |
Sunday, September 11, 1988 |
3:00PM |
DET 10, RAM 17 |
| Regular Season: Week 3 |
 Saints |
at |
Lions |
Sunday, September 18, 1988 |
3:00PM |
NO 22, DET 14 |
| Regular Season: Week 4 |
 Jets |
at |
Lions |
Sunday, September 25, 1988 |
3:00PM |
NYJ 17, DET 10 |
| Regular Season: Week 5 |
Lions |
at |
 49ers |
Sunday, October 2, 1988 |
3:00PM |
DET 13, SF 20 |
| Regular Season: Week 6 |
 Bears |
at |
Lions |
Sunday, October 9, 1988 |
3:00PM |
CHI 24, DET 7 |
| Regular Season: Week 7 |
Lions |
at |
 Giants |
Sunday, October 16, 1988 |
3:00PM |
DET 10, NYG 30 |
| Regular Season: Week 8 |
Lions |
at |
 Chiefs |
Sunday, October 23, 1988 |
3:00PM |
DET 7, KC 6 |
| Regular Season: Week 9 |
Giants |
at |
Lions |
Sunday, October 30, 1988 |
2:00PM |
NYG 13, DET 10 |
| Regular Season: Week 10 |
Lions |
at |
 Vikings |
Sunday, November 6, 1988 |
3:00PM |
DET 17, MIN 44 |
| Regular Season: Week 11 |
 Buccaneers |
at |
Lions |
Sunday, November 13, 1988 |
3:00PM |
TB 23, DET 20 |
| Regular Season: Week 12 |
Lions |
at |
 Packers |
Sunday, November 20, 1988 |
3:00PM |
DET 19, GB 9 |
| Regular Season: Week 13 |
Vikings |
at |
Lions |
Thursday, November 24, 1988 |
3:00PM |
MIN 23, DET 0 |
| Regular Season: Week 14 |
Packers |
at |
Lions |
Sunday, December 4, 1988 |
3:00PM |
GB 14, DET 30 |
| Regular Season: Week 15 |
Lions |
at |
Bears |
Sunday, December 11, 1988 |
3:00PM |
DET 12, CHI 13 |
| Regular Season: Week 16 |
Lions |
at |
Buccaneers |
Sunday, December 18, 1988 |
3:00PM |
DET 10, TB 21 |