| Regular Season: Week 1 |
 Buccaneers |
at |
 Lions |
Sunday, September 9, 1990 |
3:00PM |
TB 38, DET 21 |
| Regular Season: Week 2 |
 Falcons |
at |
Lions |
Sunday, September 16, 1990 |
3:00PM |
ATL 14, DET 21 |
| Regular Season: Week 3 |
Lions |
at |
Buccaneers |
Sunday, September 23, 1990 |
3:00PM |
DET 20, TB 23 |
| Regular Season: Week 4 |
 Packers |
at |
Lions |
Sunday, September 30, 1990 |
3:00PM |
GB 24, DET 21 |
| Regular Season: Week 5 |
Lions |
at |
 Vikings |
Sunday, October 7, 1990 |
3:00PM |
DET 34, MIN 27 |
| Regular Season: Week 6 |
Lions |
at |
 Chiefs |
Sunday, October 14, 1990 |
3:00PM |
DET 24, KC 43 |
| Regular Season: Week 8 |
Lions |
at |
 Saints |
Sunday, October 28, 1990 |
2:00PM |
DET 27, NO 10 |
| Regular Season: Week 9 |
 Redskins |
at |
Lions |
Sunday, November 4, 1990 |
3:00PM |
WAS 41, DET 38 |
| Regular Season: Week 10 |
Vikings |
at |
Lions |
Sunday, November 11, 1990 |
3:00PM |
MIN 17, DET 7 |
| Regular Season: Week 11 |
Lions |
at |
 Giants |
Sunday, November 18, 1990 |
3:00PM |
DET 0, NYG 20 |
| Regular Season: Week 12 |
 Broncos |
at |
Lions |
Thursday, November 22, 1990 |
3:00PM |
DEN 27, DET 40 |
| Regular Season: Week 13 |
Lions |
at |
 Bears |
Sunday, December 2, 1990 |
3:00PM |
DET 17, CHI 23 |
| Regular Season: Week 14 |
 Raiders |
at |
Lions |
Monday, December 10, 1990 |
3:00PM |
RAI 38, DET 31 |
| Regular Season: Week 15 |
Bears |
at |
Lions |
Sunday, December 16, 1990 |
3:00PM |
CHI 21, DET 38 |
| Regular Season: Week 16 |
Lions |
at |
Packers |
Saturday, December 22, 1990 |
3:00PM |
DET 24, GB 17 |
| Regular Season: Week 17 |
Lions |
at |
 Seahawks |
Sunday, December 30, 1990 |
3:00PM |
DET 10, SEA 30 |