| Regular Season: Week 1 |
 Lions |
at |
 Bears |
Sunday, September 12, 2010 |
1:00PM |
DET 14, CHI 19 |
| Regular Season: Week 2 |
 Eagles |
at |
Lions |
Sunday, September 19, 2010 |
1:00PM |
PHI 35, DET 32 |
| Regular Season: Week 3 |
Lions |
at |
 Vikings |
Sunday, September 26, 2010 |
1:00PM |
DET 10, MIN 24 |
| Regular Season: Week 4 |
Lions |
at |
 Packers |
Sunday, October 3, 2010 |
1:00PM |
DET 26, GB 28 |
| Regular Season: Week 5 |
 Rams |
at |
Lions |
Sunday, October 10, 2010 |
1:00PM |
STL 6, DET 44 |
| Regular Season: Week 6 |
Lions |
at |
 Giants |
Sunday, October 17, 2010 |
1:00PM |
DET 20, NYG 28 |
| Regular Season: Week 8 |
 Redskins |
at |
Lions |
Sunday, October 31, 2010 |
1:00PM |
WAS 25, DET 37 |
| Regular Season: Week 9 |
 Jets |
at |
Lions |
Sunday, November 7, 2010 |
1:00PM |
NYJ 23, DET 20 |
| Regular Season: Week 10 |
Lions |
at |
 Bills |
Sunday, November 14, 2010 |
1:00PM |
DET 12, BUF 14 |
| Regular Season: Week 11 |
Lions |
at |
 Cowboys |
Sunday, November 21, 2010 |
1:00PM |
DET 19, DAL 35 |
| Regular Season: Week 12 |
 Patriots |
at |
Lions |
Thursday, November 25, 2010 |
12:30PM |
NE 45, DET 24 |
| Regular Season: Week 13 |
Bears |
at |
Lions |
Sunday, December 5, 2010 |
1:00PM |
CHI 24, DET 20 |
| Regular Season: Week 14 |
Packers |
at |
Lions |
Sunday, December 12, 2010 |
1:00PM |
GB 3, DET 7 |
| Regular Season: Week 15 |
Lions |
at |
 Buccaneers |
Sunday, December 19, 2010 |
1:00PM |
DET 23, TB 20 |
| Regular Season: Week 16 |
Lions |
at |
 Dolphins |
Sunday, December 26, 2010 |
1:00PM |
DET 34, MIA 27 |
| Regular Season: Week 17 |
Vikings |
at |
Lions |
Sunday, January 2, 2011 |
1:00PM |
MIN 13, DET 20 |