| Regular Season: Week 1 |
 Lions |
at |
 Chargers |
Sunday, September 13, 2015 |
4:05PM |
DET 28, SD 33 |
| Regular Season: Week 2 |
Lions |
at |
 Vikings |
Sunday, September 20, 2015 |
1:00PM |
DET 16, MIN 26 |
| Regular Season: Week 3 |
 Broncos |
at |
Lions |
Sunday, September 27, 2015 |
8:30PM |
DEN 24, DET 12 |
| Regular Season: Week 4 |
Lions |
at |
 Seahawks |
Monday, October 5, 2015 |
8:30PM |
DET 10, SEA 13 |
| Regular Season: Week 5 |
 Cardinals |
at |
Lions |
Sunday, October 11, 2015 |
4:05PM |
ARI 42, DET 17 |
| Regular Season: Week 6 |
 Bears |
at |
Lions |
Sunday, October 18, 2015 |
1:00PM |
CHI 34, DET 37 |
| Regular Season: Week 7 |
Vikings |
at |
Lions |
Sunday, October 25, 2015 |
1:00PM |
MIN 28, DET 19 |
| Regular Season: Week 8 |
Lions |
at |
 Chiefs |
Sunday, November 1, 2015 |
9:30PM |
DET 10, KC 45 |
| Regular Season: Week 10 |
Lions |
at |
 Packers |
Sunday, November 15, 2015 |
1:00PM |
DET 18, GB 16 |
| Regular Season: Week 11 |
 Raiders |
at |
Lions |
Sunday, November 22, 2015 |
1:00PM |
OAK 13, DET 18 |
| Regular Season: Week 12 |
 Eagles |
at |
Lions |
Thursday, November 26, 2015 |
12:30PM |
PHI 14, DET 45 |
| Regular Season: Week 13 |
Packers |
at |
Lions |
Thursday, December 3, 2015 |
8:25PM |
GB 27, DET 23 |
| Regular Season: Week 14 |
Lions |
at |
 Rams |
Sunday, December 13, 2015 |
1:00PM |
DET 14, STL 21 |
| Regular Season: Week 15 |
Lions |
at |
 Saints |
Monday, December 21, 2015 |
8:30PM |
DET 35, NO 27 |
| Regular Season: Week 16 |
 49ers |
at |
Lions |
Sunday, December 27, 2015 |
1:00PM |
SF 17, DET 32 |
| Regular Season: Week 17 |
Lions |
at |
Bears |
Sunday, January 3, 2016 |
1:00PM |
DET 24, CHI 20 |