| Regular Season: Week 1 |
 Cardinals |
at |
 Lions |
Sunday, September 10, 2017 |
1:00PM |
ARI 23, DET 35 |
| Regular Season: Week 2 |
Lions |
at |
 Giants |
Monday, September 18, 2017 |
8:30PM |
DET 24, NYG 10 |
| Regular Season: Week 3 |
 Falcons |
at |
Lions |
Sunday, September 24, 2017 |
1:00PM |
ATL 30, DET 26 |
| Regular Season: Week 4 |
Lions |
at |
 Vikings |
Sunday, October 1, 2017 |
1:00PM |
DET 14, MIN 7 |
| Regular Season: Week 5 |
 Panthers |
at |
Lions |
Sunday, October 8, 2017 |
1:00PM |
CAR 27, DET 24 |
| Regular Season: Week 6 |
Lions |
at |
 Saints |
Sunday, October 15, 2017 |
1:00PM |
DET 38, NO 52 |
| Regular Season: Week 8 |
 Steelers |
at |
Lions |
Sunday, October 29, 2017 |
8:30PM |
PIT 20, DET 15 |
| Regular Season: Week 9 |
Lions |
at |
 Packers |
Monday, November 6, 2017 |
8:30PM |
DET 30, GB 17 |
| Regular Season: Week 10 |
 Browns |
at |
Lions |
Sunday, November 12, 2017 |
1:00PM |
CLE 24, DET 38 |
| Regular Season: Week 11 |
Lions |
at |
 Bears |
Sunday, November 19, 2017 |
1:00PM |
DET 27, CHI 24 |
| Regular Season: Week 12 |
Vikings |
at |
Lions |
Thursday, November 23, 2017 |
12:30PM |
MIN 30, DET 23 |
| Regular Season: Week 13 |
Lions |
at |
 Ravens |
Sunday, December 3, 2017 |
1:00PM |
DET 20, BAL 44 |
| Regular Season: Week 14 |
Lions |
at |
 Buccaneers |
Sunday, December 10, 2017 |
1:00PM |
DET 24, TB 21 |
| Regular Season: Week 15 |
Bears |
at |
Lions |
Saturday, December 16, 2017 |
4:30PM |
CHI 10, DET 20 |
| Regular Season: Week 16 |
Lions |
at |
 Bengals |
Sunday, December 24, 2017 |
1:00PM |
DET 17, CIN 26 |
| Regular Season: Week 17 |
Packers |
at |
Lions |
Sunday, December 31, 2017 |
1:00PM |
GB 11, DET 35 |