| Regular Season: Week 1 |
 Jets |
at |
 Lions |
Monday, September 10, 2018 |
7:10PM |
NYJ 48, DET 17 |
| Regular Season: Week 2 |
Lions |
at |
 49ers |
Sunday, September 16, 2018 |
4:05PM |
DET 27, SF 30 |
| Regular Season: Week 3 |
 Patriots |
at |
Lions |
Sunday, September 23, 2018 |
8:20PM |
NE 10, DET 26 |
| Regular Season: Week 4 |
Lions |
at |
 Cowboys |
Sunday, September 30, 2018 |
1:00PM |
DET 24, DAL 26 |
| Regular Season: Week 5 |
 Packers |
at |
Lions |
Sunday, October 7, 2018 |
1:00PM |
GB 23, DET 31 |
| Regular Season: Week 7 |
Lions |
at |
 Dolphins |
Sunday, October 21, 2018 |
1:00PM |
DET 32, MIA 21 |
| Regular Season: Week 8 |
 Seahawks |
at |
Lions |
Sunday, October 28, 2018 |
1:00PM |
SEA 28, DET 14 |
| Regular Season: Week 9 |
Lions |
at |
 Vikings |
Sunday, November 4, 2018 |
1:00PM |
DET 9, MIN 24 |
| Regular Season: Week 10 |
Lions |
at |
 Bears |
Sunday, November 11, 2018 |
1:00PM |
DET 22, CHI 34 |
| Regular Season: Week 11 |
 Panthers |
at |
Lions |
Sunday, November 18, 2018 |
1:00PM |
CAR 19, DET 20 |
| Regular Season: Week 12 |
Bears |
at |
Lions |
Thursday, November 22, 2018 |
12:30PM |
CHI 23, DET 16 |
| Regular Season: Week 13 |
 Rams |
at |
Lions |
Sunday, December 2, 2018 |
1:00PM |
LA 30, DET 16 |
| Regular Season: Week 14 |
Lions |
at |
 Cardinals |
Sunday, December 9, 2018 |
4:25PM |
DET 17, ARI 3 |
| Regular Season: Week 15 |
Lions |
at |
 Bills |
Sunday, December 16, 2018 |
1:00PM |
DET 13, BUF 14 |
| Regular Season: Week 16 |
Vikings |
at |
Lions |
Sunday, December 23, 2018 |
1:00PM |
MIN 27, DET 9 |
| Regular Season: Week 17 |
Lions |
at |
Packers |
Sunday, December 30, 2018 |
1:00PM |
DET 31, GB 0 |