| Regular Season: Week 1 |
 Lions |
at |
 Cardinals |
Sunday, September 8, 2019 |
4:25PM |
DET 27, ARI 27 |
| Regular Season: Week 2 |
 Chargers |
at |
Lions |
Sunday, September 15, 2019 |
1:00PM |
LAC 10, DET 13 |
| Regular Season: Week 3 |
Lions |
at |
 Eagles |
Sunday, September 22, 2019 |
1:00PM |
DET 27, PHI 24 |
| Regular Season: Week 4 |
 Chiefs |
at |
Lions |
Sunday, September 29, 2019 |
1:00PM |
KC 34, DET 30 |
| Regular Season: Week 6 |
Lions |
at |
 Packers |
Monday, October 14, 2019 |
8:15PM |
DET 22, GB 23 |
| Regular Season: Week 7 |
 Vikings |
at |
Lions |
Sunday, October 20, 2019 |
1:00PM |
MIN 42, DET 30 |
| Regular Season: Week 8 |
 Giants |
at |
Lions |
Sunday, October 27, 2019 |
1:00PM |
NYG 26, DET 31 |
| Regular Season: Week 9 |
Lions |
at |
 Raiders |
Sunday, November 3, 2019 |
4:05PM |
DET 24, OAK 31 |
| Regular Season: Week 10 |
Lions |
at |
 Bears |
Sunday, November 10, 2019 |
1:00PM |
DET 13, CHI 20 |
| Regular Season: Week 11 |
 Cowboys |
at |
Lions |
Sunday, November 17, 2019 |
1:00PM |
DAL 35, DET 27 |
| Regular Season: Week 12 |
Lions |
at |
 Redskins |
Sunday, November 24, 2019 |
1:00PM |
DET 16, WAS 19 |
| Regular Season: Week 13 |
Bears |
at |
Lions |
Thursday, November 28, 2019 |
12:30PM |
CHI 24, DET 20 |
| Regular Season: Week 14 |
Lions |
at |
Vikings |
Sunday, December 8, 2019 |
1:00PM |
DET 7, MIN 20 |
| Regular Season: Week 15 |
 Buccaneers |
at |
Lions |
Sunday, December 15, 2019 |
1:00PM |
TB 38, DET 17 |
| Regular Season: Week 16 |
Lions |
at |
 Broncos |
Sunday, December 22, 2019 |
4:05PM |
DET 17, DEN 27 |
| Regular Season: Week 17 |
Packers |
at |
Lions |
Sunday, December 29, 2019 |
1:00PM |
GB 23, DET 20 |