| Regular Season: Week 1 |
 49ers |
at |
 Lions |
Sunday, September 12, 2021 |
1:00PM |
SF 41, DET 33 |
| Regular Season: Week 2 |
Lions |
at |
 Packers |
Monday, September 20, 2021 |
8:15PM |
DET 17, GB 35 |
| Regular Season: Week 3 |
 Ravens |
at |
Lions |
Sunday, September 26, 2021 |
1:00PM |
BAL 19, DET 17 |
| Regular Season: Week 4 |
Lions |
at |
 Bears |
Sunday, October 3, 2021 |
1:00PM |
DET 14, CHI 24 |
| Regular Season: Week 5 |
Lions |
at |
 Vikings |
Sunday, October 10, 2021 |
1:00PM |
DET 17, MIN 19 |
| Regular Season: Week 6 |
 Bengals |
at |
Lions |
Sunday, October 17, 2021 |
1:00PM |
CIN 34, DET 11 |
| Regular Season: Week 7 |
Lions |
at |
 Rams |
Sunday, October 24, 2021 |
4:05PM |
DET 19, LAR 28 |
| Regular Season: Week 8 |
 Eagles |
at |
Lions |
Sunday, October 31, 2021 |
1:00PM |
PHI 44, DET 6 |
| Regular Season: Week 10 |
Lions |
at |
 Steelers |
Sunday, November 14, 2021 |
1:00PM |
DET 16, PIT 16 |
| Regular Season: Week 11 |
Lions |
at |
 Browns |
Sunday, November 21, 2021 |
1:00PM |
DET 10, CLE 13 |
| Regular Season: Week 12 |
Bears |
at |
Lions |
Thursday, November 25, 2021 |
12:30PM |
CHI 16, DET 14 |
| Regular Season: Week 13 |
Vikings |
at |
Lions |
Sunday, December 5, 2021 |
1:00PM |
MIN 27, DET 29 |
| Regular Season: Week 14 |
Lions |
at |
 Broncos |
Sunday, December 12, 2021 |
4:05PM |
DET 10, DEN 38 |
| Regular Season: Week 15 |
 Cardinals |
at |
Lions |
Sunday, December 19, 2021 |
1:00PM |
ARI 12, DET 30 |
| Regular Season: Week 16 |
Lions |
at |
 Falcons |
Sunday, December 26, 2021 |
1:00PM |
DET 16, ATL 20 |
| Regular Season: Week 17 |
Lions |
at |
 Seahawks |
Sunday, January 2, 2022 |
4:25PM |
DET 29, SEA 51 |
| Regular Season: Week 18 |
Packers |
at |
Lions |
Sunday, January 9, 2022 |
1:00PM |
GB 30, DET 37 |