| Regular Season: Week 1 |
 Bears |
at |
 Packers |
Sunday, September 7, 1980 |
3:00PM |
CHI 6, GB 12 |
| Regular Season: Week 2 |
 Lions |
at |
Packers |
Sunday, September 14, 1980 |
3:00PM |
DET 29, GB 7 |
| Regular Season: Week 3 |
Packers |
at |
 Rams |
Sunday, September 21, 1980 |
3:00PM |
GB 21, LA 51 |
| Regular Season: Week 4 |
 Cowboys |
at |
Packers |
Sunday, September 28, 1980 |
3:00PM |
DAL 28, GB 7 |
| Regular Season: Week 5 |
 Bengals |
at |
Packers |
Sunday, October 5, 1980 |
3:00PM |
CIN 9, GB 14 |
| Regular Season: Week 6 |
Packers |
at |
 Buccaneers |
Sunday, October 12, 1980 |
3:00PM |
GB 14, TB 14 |
| Regular Season: Week 7 |
Packers |
at |
 Browns |
Sunday, October 19, 1980 |
3:00PM |
GB 21, CLE 26 |
| Regular Season: Week 8 |
 Vikings |
at |
Packers |
Sunday, October 26, 1980 |
2:00PM |
MIN 3, GB 16 |
| Regular Season: Week 9 |
Packers |
at |
 Steelers |
Sunday, November 2, 1980 |
3:00PM |
GB 20, PIT 22 |
| Regular Season: Week 10 |
 49ers |
at |
Packers |
Sunday, November 9, 1980 |
3:00PM |
SF 16, GB 23 |
| Regular Season: Week 11 |
Packers |
at |
 Giants |
Sunday, November 16, 1980 |
3:00PM |
GB 21, NYG 27 |
| Regular Season: Week 12 |
Packers |
at |
Vikings |
Sunday, November 23, 1980 |
3:00PM |
GB 25, MIN 13 |
| Regular Season: Week 13 |
Buccaneers |
at |
Packers |
Sunday, November 30, 1980 |
3:00PM |
TB 20, GB 17 |
| Regular Season: Week 14 |
Packers |
at |
Bears |
Sunday, December 7, 1980 |
3:00PM |
GB 7, CHI 61 |
| Regular Season: Week 15 |
 Oilers |
at |
Packers |
Sunday, December 14, 1980 |
3:00PM |
HOU 22, GB 3 |
| Regular Season: Week 16 |
Packers |
at |
Lions |
Sunday, December 21, 1980 |
3:00PM |
GB 3, DET 24 |