| Regular Season: Week 1 |
 Panthers |
at |
 Redskins |
Sunday, September 3, 2000 |
1:00PM |
CAR 17, WAS 20 |
| Regular Season: Week 2 |
Panthers |
at |
 49ers |
Sunday, September 10, 2000 |
4:15PM |
CAR 38, SF 22 |
| Regular Season: Week 3 |
 Falcons |
at |
Panthers |
Sunday, September 17, 2000 |
1:00PM |
ATL 15, CAR 10 |
| Regular Season: Week 5 |
 Cowboys |
at |
Panthers |
Sunday, October 1, 2000 |
1:00PM |
DAL 16, CAR 13 |
| Regular Season: Week 6 |
 Seahawks |
at |
Panthers |
Sunday, October 8, 2000 |
4:15PM |
SEA 3, CAR 26 |
| Regular Season: Week 7 |
Panthers |
at |
 Saints |
Sunday, October 15, 2000 |
1:00PM |
CAR 6, NO 24 |
| Regular Season: Week 8 |
49ers |
at |
Panthers |
Sunday, October 22, 2000 |
1:00PM |
SF 16, CAR 34 |
| Regular Season: Week 9 |
Panthers |
at |
Falcons |
Sunday, October 29, 2000 |
1:00PM |
CAR 12, ATL 13 |
| Regular Season: Week 10 |
Panthers |
at |
 Rams |
Sunday, November 5, 2000 |
8:20PM |
CAR 27, STL 24 |
| Regular Season: Week 11 |
Saints |
at |
Panthers |
Sunday, November 12, 2000 |
1:00PM |
NO 20, CAR 10 |
| Regular Season: Week 12 |
Panthers |
at |
 Vikings |
Sunday, November 19, 2000 |
1:00PM |
CAR 17, MIN 31 |
| Regular Season: Week 13 |
 Packers |
at |
Panthers |
Monday, November 27, 2000 |
9:00PM |
GB 14, CAR 31 |
| Regular Season: Week 14 |
Rams |
at |
Panthers |
Sunday, December 3, 2000 |
1:00PM |
STL 3, CAR 16 |
| Regular Season: Week 15 |
Panthers |
at |
 Chiefs |
Sunday, December 10, 2000 |
1:00PM |
CAR 14, KC 15 |
| Regular Season: Week 16 |
 Chargers |
at |
Panthers |
Sunday, December 17, 2000 |
1:00PM |
SD 22, CAR 30 |
| Regular Season: Week 17 |
Panthers |
at |
 Raiders |
Sunday, December 24, 2000 |
4:15PM |
CAR 9, OAK 52 |