| Regular Season: Week 1 |
 Redskins |
at |
 Patriots |
Sunday, September 3, 1978 |
3:00PM |
WAS 16, NE 14 |
| Regular Season: Week 2 |
Patriots |
at |
 Cardinals |
Sunday, September 10, 1978 |
3:00PM |
NE 16, STL 6 |
| Regular Season: Week 3 |
 Colts |
at |
Patriots |
Monday, September 18, 1978 |
3:00PM |
BAL 34, NE 27 |
| Regular Season: Week 4 |
Patriots |
at |
 Raiders |
Sunday, September 24, 1978 |
3:00PM |
NE 21, OAK 14 |
| Regular Season: Week 5 |
 Chargers |
at |
Patriots |
Sunday, October 1, 1978 |
3:00PM |
SD 23, NE 28 |
| Regular Season: Week 6 |
 Eagles |
at |
Patriots |
Sunday, October 8, 1978 |
3:00PM |
PHI 14, NE 24 |
| Regular Season: Week 7 |
Patriots |
at |
 Bengals |
Sunday, October 15, 1978 |
3:00PM |
NE 10, CIN 3 |
| Regular Season: Week 8 |
 Dolphins |
at |
Patriots |
Sunday, October 22, 1978 |
3:00PM |
MIA 24, NE 33 |
| Regular Season: Week 9 |
 Jets |
at |
Patriots |
Sunday, October 29, 1978 |
2:00PM |
NYJ 21, NE 55 |
| Regular Season: Week 10 |
Patriots |
at |
 Bills |
Sunday, November 5, 1978 |
3:00PM |
NE 14, BUF 10 |
| Regular Season: Week 11 |
 Oilers |
at |
Patriots |
Sunday, November 12, 1978 |
3:00PM |
HOU 26, NE 23 |
| Regular Season: Week 12 |
Patriots |
at |
Jets |
Sunday, November 19, 1978 |
3:00PM |
NE 19, NYJ 17 |
| Regular Season: Week 13 |
Patriots |
at |
Colts |
Sunday, November 26, 1978 |
3:00PM |
NE 35, BAL 14 |
| Regular Season: Week 14 |
Patriots |
at |
 Cowboys |
Sunday, December 3, 1978 |
3:00PM |
NE 10, DAL 17 |
| Regular Season: Week 15 |
Bills |
at |
Patriots |
Sunday, December 10, 1978 |
3:00PM |
BUF 24, NE 26 |
| Regular Season: Week 16 |
Patriots |
at |
Dolphins |
Monday, December 18, 1978 |
3:00PM |
NE 3, MIA 23 |
| Divisional Playoffs: Week 18 |
Oilers |
at |
Patriots |
Sunday, December 31, 1978 |
3:00PM |
HOU 31, NE 14 |