| Regular Season: Week 1 |
 Browns |
at |
 Patriots |
Sunday, September 7, 1980 |
3:00PM |
CLE 17, NE 34 |
| Regular Season: Week 2 |
 Falcons |
at |
Patriots |
Sunday, September 14, 1980 |
3:00PM |
ATL 37, NE 21 |
| Regular Season: Week 3 |
Patriots |
at |
 Seahawks |
Sunday, September 21, 1980 |
3:00PM |
NE 37, SEA 31 |
| Regular Season: Week 4 |
 Broncos |
at |
Patriots |
Monday, September 29, 1980 |
3:00PM |
DEN 14, NE 23 |
| Regular Season: Week 5 |
Patriots |
at |
 Jets |
Sunday, October 5, 1980 |
3:00PM |
NE 21, NYJ 11 |
| Regular Season: Week 6 |
 Dolphins |
at |
Patriots |
Sunday, October 12, 1980 |
3:00PM |
MIA 0, NE 34 |
| Regular Season: Week 7 |
Patriots |
at |
 Colts |
Sunday, October 19, 1980 |
3:00PM |
NE 37, BAL 21 |
| Regular Season: Week 8 |
Patriots |
at |
 Bills |
Sunday, October 26, 1980 |
2:00PM |
NE 13, BUF 31 |
| Regular Season: Week 9 |
Jets |
at |
Patriots |
Sunday, November 2, 1980 |
3:00PM |
NYJ 21, NE 34 |
| Regular Season: Week 10 |
Patriots |
at |
 Oilers |
Monday, November 10, 1980 |
3:00PM |
NE 34, HOU 38 |
| Regular Season: Week 11 |
 Rams |
at |
Patriots |
Sunday, November 16, 1980 |
3:00PM |
LA 17, NE 14 |
| Regular Season: Week 12 |
Colts |
at |
Patriots |
Sunday, November 23, 1980 |
3:00PM |
BAL 21, NE 47 |
| Regular Season: Week 13 |
Patriots |
at |
 49ers |
Sunday, November 30, 1980 |
3:00PM |
NE 17, SF 21 |
| Regular Season: Week 14 |
Patriots |
at |
Dolphins |
Monday, December 8, 1980 |
3:00PM |
NE 13, MIA 16 |
| Regular Season: Week 15 |
Bills |
at |
Patriots |
Sunday, December 14, 1980 |
3:00PM |
BUF 2, NE 24 |
| Regular Season: Week 16 |
Patriots |
at |
 Saints |
Sunday, December 21, 1980 |
3:00PM |
NE 38, NO 27 |