| Regular Season: Week 1 |
 Jets |
at |
 Patriots |
Sunday, September 4, 1988 |
3:00PM |
NYJ 3, NE 28 |
| Regular Season: Week 2 |
Patriots |
at |
 Vikings |
Sunday, September 11, 1988 |
3:00PM |
NE 6, MIN 36 |
| Regular Season: Week 3 |
 Bills |
at |
Patriots |
Sunday, September 18, 1988 |
3:00PM |
BUF 16, NE 14 |
| Regular Season: Week 4 |
Patriots |
at |
 Oilers |
Sunday, September 25, 1988 |
3:00PM |
NE 6, HOU 31 |
| Regular Season: Week 5 |
 Colts |
at |
Patriots |
Sunday, October 2, 1988 |
3:00PM |
IND 17, NE 21 |
| Regular Season: Week 6 |
Patriots |
at |
 Packers |
Sunday, October 9, 1988 |
3:00PM |
NE 3, GB 45 |
| Regular Season: Week 7 |
 Bengals |
at |
Patriots |
Sunday, October 16, 1988 |
3:00PM |
CIN 21, NE 27 |
| Regular Season: Week 8 |
Patriots |
at |
Bills |
Sunday, October 23, 1988 |
3:00PM |
NE 20, BUF 23 |
| Regular Season: Week 9 |
 Bears |
at |
Patriots |
Sunday, October 30, 1988 |
2:00PM |
CHI 7, NE 30 |
| Regular Season: Week 10 |
 Dolphins |
at |
Patriots |
Sunday, November 6, 1988 |
3:00PM |
MIA 10, NE 21 |
| Regular Season: Week 11 |
Patriots |
at |
Jets |
Sunday, November 13, 1988 |
3:00PM |
NE 14, NYJ 13 |
| Regular Season: Week 12 |
Patriots |
at |
Dolphins |
Sunday, November 20, 1988 |
3:00PM |
NE 6, MIA 3 |
| Regular Season: Week 13 |
Patriots |
at |
Colts |
Sunday, November 27, 1988 |
3:00PM |
NE 21, IND 24 |
| Regular Season: Week 14 |
 Seahawks |
at |
Patriots |
Sunday, December 4, 1988 |
3:00PM |
SEA 7, NE 13 |
| Regular Season: Week 15 |
 Buccaneers |
at |
Patriots |
Sunday, December 11, 1988 |
3:00PM |
TB 7, NE 10 |
| Regular Season: Week 16 |
Patriots |
at |
 Broncos |
Saturday, December 17, 1988 |
3:00PM |
NE 10, DEN 21 |