| Regular Season: Week 1 |
 Dolphins |
at |
 Patriots |
Sunday, September 9, 1990 |
3:00PM |
MIA 27, NE 24 |
| Regular Season: Week 2 |
Patriots |
at |
 Colts |
Sunday, September 16, 1990 |
3:00PM |
NE 16, IND 14 |
| Regular Season: Week 3 |
Patriots |
at |
 Bengals |
Sunday, September 23, 1990 |
3:00PM |
NE 7, CIN 41 |
| Regular Season: Week 4 |
 Jets |
at |
Patriots |
Sunday, September 30, 1990 |
3:00PM |
NYJ 37, NE 13 |
| Regular Season: Week 5 |
 Seahawks |
at |
Patriots |
Sunday, October 7, 1990 |
3:00PM |
SEA 33, NE 20 |
| Regular Season: Week 7 |
Patriots |
at |
Dolphins |
Thursday, October 18, 1990 |
3:00PM |
NE 10, MIA 17 |
| Regular Season: Week 8 |
 Bills |
at |
Patriots |
Sunday, October 28, 1990 |
2:00PM |
BUF 27, NE 10 |
| Regular Season: Week 9 |
Patriots |
at |
 Eagles |
Sunday, November 4, 1990 |
3:00PM |
NE 20, PHI 48 |
| Regular Season: Week 10 |
Colts |
at |
Patriots |
Sunday, November 11, 1990 |
3:00PM |
IND 13, NE 10 |
| Regular Season: Week 11 |
Patriots |
at |
Bills |
Sunday, November 18, 1990 |
3:00PM |
NE 0, BUF 14 |
| Regular Season: Week 12 |
Patriots |
at |
 Cardinals |
Sunday, November 25, 1990 |
3:00PM |
NE 14, PHO 34 |
| Regular Season: Week 13 |
 Chiefs |
at |
Patriots |
Sunday, December 2, 1990 |
3:00PM |
KC 37, NE 7 |
| Regular Season: Week 14 |
Patriots |
at |
 Steelers |
Sunday, December 9, 1990 |
3:00PM |
NE 3, PIT 24 |
| Regular Season: Week 15 |
 Redskins |
at |
Patriots |
Saturday, December 15, 1990 |
3:00PM |
WAS 25, NE 10 |
| Regular Season: Week 16 |
Patriots |
at |
Jets |
Sunday, December 23, 1990 |
3:00PM |
NE 7, NYJ 42 |
| Regular Season: Week 17 |
 Giants |
at |
Patriots |
Sunday, December 30, 1990 |
3:00PM |
NYG 13, NE 10 |