| Regular Season: Week 1 |
 Patriots |
at |
 Colts |
Sunday, September 1, 1991 |
3:00PM |
NE 16, IND 7 |
| Regular Season: Week 2 |
 Browns |
at |
Patriots |
Sunday, September 8, 1991 |
3:00PM |
CLE 20, NE 0 |
| Regular Season: Week 3 |
Patriots |
at |
 Steelers |
Sunday, September 15, 1991 |
3:00PM |
NE 6, PIT 20 |
| Regular Season: Week 4 |
 Oilers |
at |
Patriots |
Sunday, September 22, 1991 |
3:00PM |
HOU 20, NE 24 |
| Regular Season: Week 5 |
Patriots |
at |
 Cardinals |
Sunday, September 29, 1991 |
3:00PM |
NE 10, PHO 24 |
| Regular Season: Week 6 |
 Dolphins |
at |
Patriots |
Sunday, October 6, 1991 |
3:00PM |
MIA 20, NE 10 |
| Regular Season: Week 8 |
 Vikings |
at |
Patriots |
Sunday, October 20, 1991 |
3:00PM |
MIN 23, NE 26 |
| Regular Season: Week 9 |
 Broncos |
at |
Patriots |
Sunday, October 27, 1991 |
2:00PM |
DEN 9, NE 6 |
| Regular Season: Week 10 |
Patriots |
at |
 Bills |
Sunday, November 3, 1991 |
3:00PM |
NE 17, BUF 22 |
| Regular Season: Week 11 |
Patriots |
at |
Dolphins |
Sunday, November 10, 1991 |
3:00PM |
NE 20, MIA 30 |
| Regular Season: Week 12 |
 Jets |
at |
Patriots |
Sunday, November 17, 1991 |
3:00PM |
NYJ 28, NE 21 |
| Regular Season: Week 13 |
Bills |
at |
Patriots |
Sunday, November 24, 1991 |
3:00PM |
BUF 13, NE 16 |
| Regular Season: Week 14 |
Patriots |
at |
Broncos |
Sunday, December 1, 1991 |
3:00PM |
NE 3, DEN 20 |
| Regular Season: Week 15 |
Colts |
at |
Patriots |
Sunday, December 8, 1991 |
3:00PM |
IND 17, NE 23 |
| Regular Season: Week 16 |
Patriots |
at |
Jets |
Sunday, December 15, 1991 |
3:00PM |
NE 6, NYJ 3 |
| Regular Season: Week 17 |
Patriots |
at |
 Bengals |
Sunday, December 22, 1991 |
3:00PM |
NE 7, CIN 29 |