| Regular Season: Week 1 |
 Buccaneers |
at |
 Patriots |
Sunday, September 3, 2000 |
1:00PM |
TB 21, NE 16 |
| Regular Season: Week 2 |
Patriots |
at |
 Jets |
Monday, September 11, 2000 |
9:00PM |
NE 19, NYJ 20 |
| Regular Season: Week 3 |
 Vikings |
at |
Patriots |
Sunday, September 17, 2000 |
4:15PM |
MIN 21, NE 13 |
| Regular Season: Week 4 |
Patriots |
at |
 Dolphins |
Sunday, September 24, 2000 |
1:00PM |
NE 3, MIA 10 |
| Regular Season: Week 5 |
Patriots |
at |
 Broncos |
Sunday, October 1, 2000 |
4:05PM |
NE 28, DEN 19 |
| Regular Season: Week 6 |
 Colts |
at |
Patriots |
Sunday, October 8, 2000 |
1:00PM |
IND 16, NE 24 |
| Regular Season: Week 7 |
Jets |
at |
Patriots |
Sunday, October 15, 2000 |
4:05PM |
NYJ 34, NE 17 |
| Regular Season: Week 8 |
Patriots |
at |
Colts |
Sunday, October 22, 2000 |
12:00PM |
NE 23, IND 30 |
| Regular Season: Week 10 |
 Bills |
at |
Patriots |
Sunday, November 5, 2000 |
1:00PM |
BUF 16, NE 13 |
| Regular Season: Week 11 |
Patriots |
at |
 Browns |
Sunday, November 12, 2000 |
1:05PM |
NE 11, CLE 19 |
| Regular Season: Week 12 |
 Bengals |
at |
Patriots |
Sunday, November 19, 2000 |
1:00PM |
CIN 13, NE 16 |
| Regular Season: Week 13 |
Patriots |
at |
 Lions |
Thursday, November 23, 2000 |
12:30PM |
NE 9, DET 34 |
| Regular Season: Week 14 |
 Chiefs |
at |
Patriots |
Monday, December 4, 2000 |
9:00PM |
KC 24, NE 30 |
| Regular Season: Week 15 |
Patriots |
at |
 Bears |
Sunday, December 10, 2000 |
1:00PM |
NE 17, CHI 24 |
| Regular Season: Week 16 |
Patriots |
at |
Bills |
Sunday, December 17, 2000 |
1:00PM |
NE 13, BUF 10 |
| Regular Season: Week 17 |
Dolphins |
at |
Patriots |
Sunday, December 24, 2000 |
1:00PM |
MIA 27, NE 24 |