| Regular Season: Week 1 |
 Dolphins |
at |
 Patriots |
Sunday, September 12, 2021 |
4:25PM |
MIA 17, NE 16 |
| Regular Season: Week 2 |
Patriots |
at |
 Jets |
Sunday, September 19, 2021 |
1:00PM |
NE 25, NYJ 6 |
| Regular Season: Week 3 |
 Saints |
at |
Patriots |
Sunday, September 26, 2021 |
1:00PM |
NO 28, NE 13 |
| Regular Season: Week 4 |
 Buccaneers |
at |
Patriots |
Sunday, October 3, 2021 |
8:20PM |
TB 19, NE 17 |
| Regular Season: Week 5 |
Patriots |
at |
 Texans |
Sunday, October 10, 2021 |
1:00PM |
NE 25, HOU 22 |
| Regular Season: Week 6 |
 Cowboys |
at |
Patriots |
Sunday, October 17, 2021 |
4:25PM |
DAL 35, NE 29 |
| Regular Season: Week 7 |
Jets |
at |
Patriots |
Sunday, October 24, 2021 |
1:00PM |
NYJ 13, NE 54 |
| Regular Season: Week 8 |
Patriots |
at |
 Chargers |
Sunday, October 31, 2021 |
4:05PM |
NE 27, LAC 24 |
| Regular Season: Week 9 |
Patriots |
at |
 Panthers |
Sunday, November 7, 2021 |
1:00PM |
NE 24, CAR 6 |
| Regular Season: Week 10 |
 Browns |
at |
Patriots |
Sunday, November 14, 2021 |
1:00PM |
CLE 7, NE 45 |
| Regular Season: Week 11 |
Patriots |
at |
 Falcons |
Thursday, November 18, 2021 |
8:20PM |
NE 25, ATL 0 |
| Regular Season: Week 12 |
 Titans |
at |
Patriots |
Sunday, November 28, 2021 |
1:00PM |
TEN 13, NE 36 |
| Regular Season: Week 13 |
Patriots |
at |
 Bills |
Monday, December 6, 2021 |
8:15PM |
NE 14, BUF 10 |
| Regular Season: Week 15 |
Patriots |
at |
 Colts |
Sunday, December 19, 2021 |
TBD |
NE 17, IND 27 |
| Regular Season: Week 16 |
Bills |
at |
Patriots |
Sunday, December 26, 2021 |
1:00PM |
BUF 33, NE 21 |
| Regular Season: Week 17 |
 Jaguars |
at |
Patriots |
Sunday, January 2, 2022 |
1:00PM |
JAX 10, NE 50 |
| Regular Season: Week 18 |
Patriots |
at |
Dolphins |
Sunday, January 9, 2022 |
1:00PM |
NE 24, MIA 33 |