| Regular Season: Week 1 |
 Lions |
at |
 Rams |
Sunday, September 7, 1980 |
3:00PM |
DET 41, LA 20 |
| Regular Season: Week 2 |
Rams |
at |
 Buccaneers |
Thursday, September 11, 1980 |
3:00PM |
LA 9, TB 10 |
| Regular Season: Week 3 |
 Packers |
at |
Rams |
Sunday, September 21, 1980 |
3:00PM |
GB 21, LA 51 |
| Regular Season: Week 4 |
Rams |
at |
 Giants |
Sunday, September 28, 1980 |
3:00PM |
LA 28, NYG 7 |
| Regular Season: Week 5 |
 49ers |
at |
Rams |
Sunday, October 5, 1980 |
3:00PM |
SF 26, LA 48 |
| Regular Season: Week 6 |
Rams |
at |
 Cardinals |
Sunday, October 12, 1980 |
3:00PM |
LA 21, STL 13 |
| Regular Season: Week 7 |
Rams |
at |
49ers |
Sunday, October 19, 1980 |
3:00PM |
LA 31, SF 17 |
| Regular Season: Week 8 |
Rams |
at |
 Falcons |
Sunday, October 26, 1980 |
2:00PM |
LA 10, ATL 13 |
| Regular Season: Week 9 |
 Saints |
at |
Rams |
Sunday, November 2, 1980 |
3:00PM |
NO 31, LA 45 |
| Regular Season: Week 10 |
 Dolphins |
at |
Rams |
Sunday, November 9, 1980 |
3:00PM |
MIA 35, LA 14 |
| Regular Season: Week 11 |
Rams |
at |
 Patriots |
Sunday, November 16, 1980 |
3:00PM |
LA 17, NE 14 |
| Regular Season: Week 12 |
Rams |
at |
Saints |
Monday, November 24, 1980 |
3:00PM |
LA 27, NO 7 |
| Regular Season: Week 13 |
 Jets |
at |
Rams |
Sunday, November 30, 1980 |
3:00PM |
NYJ 13, LA 38 |
| Regular Season: Week 14 |
Rams |
at |
 Bills |
Sunday, December 7, 1980 |
3:00PM |
LA 7, BUF 10 |
| Regular Season: Week 15 |
 Cowboys |
at |
Rams |
Monday, December 15, 1980 |
3:00PM |
DAL 14, LA 38 |
| Regular Season: Week 16 |
Falcons |
at |
Rams |
Sunday, December 21, 1980 |
3:00PM |
ATL 17, LA 20 |
| Wild Card: Week 17 |
Rams |
at |
Cowboys |
Sunday, December 28, 1980 |
3:00PM |
LA 13, DAL 34 |