| Regular Season: Week 1 |
 Oilers |
at |
 Rams |
Sunday, September 6, 1981 |
3:00PM |
HOU 27, LA 20 |
| Regular Season: Week 2 |
Rams |
at |
 Saints |
Sunday, September 13, 1981 |
3:00PM |
LA 17, NO 23 |
| Regular Season: Week 3 |
 Packers |
at |
Rams |
Sunday, September 20, 1981 |
3:00PM |
GB 23, LA 35 |
| Regular Season: Week 4 |
Rams |
at |
 Bears |
Monday, September 28, 1981 |
3:00PM |
LA 24, CHI 7 |
| Regular Season: Week 5 |
 Browns |
at |
Rams |
Sunday, October 4, 1981 |
3:00PM |
CLE 16, LA 27 |
| Regular Season: Week 6 |
Rams |
at |
 Falcons |
Sunday, October 11, 1981 |
3:00PM |
LA 37, ATL 35 |
| Regular Season: Week 7 |
Rams |
at |
 Cowboys |
Sunday, October 18, 1981 |
3:00PM |
LA 17, DAL 29 |
| Regular Season: Week 8 |
Rams |
at |
 49ers |
Sunday, October 25, 1981 |
2:00PM |
LA 17, SF 20 |
| Regular Season: Week 9 |
 Lions |
at |
Rams |
Sunday, November 1, 1981 |
3:00PM |
DET 13, LA 20 |
| Regular Season: Week 10 |
Saints |
at |
Rams |
Sunday, November 8, 1981 |
3:00PM |
NO 21, LA 13 |
| Regular Season: Week 11 |
Rams |
at |
 Bengals |
Sunday, November 15, 1981 |
3:00PM |
LA 10, CIN 24 |
| Regular Season: Week 12 |
49ers |
at |
Rams |
Sunday, November 22, 1981 |
3:00PM |
SF 33, LA 31 |
| Regular Season: Week 13 |
Rams |
at |
 Steelers |
Sunday, November 29, 1981 |
3:00PM |
LA 0, PIT 24 |
| Regular Season: Week 14 |
Rams |
at |
 Giants |
Sunday, December 6, 1981 |
3:00PM |
LA 7, NYG 10 |
| Regular Season: Week 15 |
Falcons |
at |
Rams |
Monday, December 14, 1981 |
3:00PM |
ATL 16, LA 21 |
| Regular Season: Week 16 |
 Redskins |
at |
Rams |
Sunday, December 20, 1981 |
3:00PM |
WAS 30, LA 7 |