| Regular Season: Week 1 |
 Broncos |
at |
 Rams |
Monday, September 4, 2000 |
9:00PM |
DEN 36, STL 41 |
| Regular Season: Week 2 |
Rams |
at |
 Seahawks |
Sunday, September 10, 2000 |
4:15PM |
STL 37, SEA 34 |
| Regular Season: Week 3 |
 49ers |
at |
Rams |
Sunday, September 17, 2000 |
1:00PM |
SF 24, STL 41 |
| Regular Season: Week 4 |
Rams |
at |
 Falcons |
Sunday, September 24, 2000 |
1:00PM |
STL 41, ATL 20 |
| Regular Season: Week 5 |
 Chargers |
at |
Rams |
Sunday, October 1, 2000 |
1:00PM |
SD 31, STL 57 |
| Regular Season: Week 7 |
Falcons |
at |
Rams |
Sunday, October 15, 2000 |
1:00PM |
ATL 29, STL 45 |
| Regular Season: Week 8 |
Rams |
at |
 Chiefs |
Sunday, October 22, 2000 |
1:00PM |
STL 34, KC 54 |
| Regular Season: Week 9 |
Rams |
at |
49ers |
Sunday, October 29, 2000 |
4:05PM |
STL 34, SF 24 |
| Regular Season: Week 10 |
 Panthers |
at |
Rams |
Sunday, November 5, 2000 |
8:20PM |
CAR 27, STL 24 |
| Regular Season: Week 11 |
Rams |
at |
 Giants |
Sunday, November 12, 2000 |
4:15PM |
STL 38, NYG 24 |
| Regular Season: Week 12 |
 Redskins |
at |
Rams |
Monday, November 20, 2000 |
9:00PM |
WAS 33, STL 20 |
| Regular Season: Week 13 |
 Saints |
at |
Rams |
Sunday, November 26, 2000 |
1:00PM |
NO 31, STL 24 |
| Regular Season: Week 14 |
Rams |
at |
Panthers |
Sunday, December 3, 2000 |
1:00PM |
STL 3, CAR 16 |
| Regular Season: Week 15 |
 Vikings |
at |
Rams |
Sunday, December 10, 2000 |
4:15PM |
MIN 29, STL 40 |
| Regular Season: Week 16 |
Rams |
at |
 Buccaneers |
Monday, December 18, 2000 |
9:00PM |
STL 35, TB 38 |
| Regular Season: Week 17 |
Rams |
at |
Saints |
Sunday, December 24, 2000 |
1:00PM |
STL 26, NO 21 |
| Wild Card: Week 18 |
Rams |
at |
Saints |
Saturday, December 30, 2000 |
4:00PM |
STL 28, NO 31 |