| Regular Season: Week 1 |
 Cardinals |
at |
 Rams |
Sunday, September 12, 2010 |
4:15PM |
ARI 17, STL 13 |
| Regular Season: Week 2 |
Rams |
at |
 Raiders |
Sunday, September 19, 2010 |
4:05PM |
STL 14, OAK 16 |
| Regular Season: Week 3 |
 Redskins |
at |
Rams |
Sunday, September 26, 2010 |
4:05PM |
WAS 16, STL 30 |
| Regular Season: Week 4 |
 Seahawks |
at |
Rams |
Sunday, October 3, 2010 |
1:00PM |
SEA 3, STL 20 |
| Regular Season: Week 5 |
Rams |
at |
 Lions |
Sunday, October 10, 2010 |
1:00PM |
STL 6, DET 44 |
| Regular Season: Week 6 |
 Chargers |
at |
Rams |
Sunday, October 17, 2010 |
1:00PM |
SD 17, STL 20 |
| Regular Season: Week 7 |
Rams |
at |
 Buccaneers |
Sunday, October 24, 2010 |
1:00PM |
STL 17, TB 18 |
| Regular Season: Week 8 |
 Panthers |
at |
Rams |
Sunday, October 31, 2010 |
1:00PM |
CAR 10, STL 20 |
| Regular Season: Week 10 |
Rams |
at |
 49ers |
Sunday, November 14, 2010 |
4:15PM |
STL 20, SF 23 |
| Regular Season: Week 11 |
 Falcons |
at |
Rams |
Sunday, November 21, 2010 |
4:05PM |
ATL 34, STL 17 |
| Regular Season: Week 12 |
Rams |
at |
 Broncos |
Sunday, November 28, 2010 |
4:15PM |
STL 36, DEN 33 |
| Regular Season: Week 13 |
Rams |
at |
Cardinals |
Sunday, December 5, 2010 |
4:15PM |
STL 19, ARI 6 |
| Regular Season: Week 14 |
Rams |
at |
 Saints |
Sunday, December 12, 2010 |
4:05PM |
STL 13, NO 31 |
| Regular Season: Week 15 |
 Chiefs |
at |
Rams |
Sunday, December 19, 2010 |
1:00PM |
KC 27, STL 13 |
| Regular Season: Week 16 |
49ers |
at |
Rams |
Sunday, December 26, 2010 |
1:00PM |
SF 17, STL 25 |
| Regular Season: Week 17 |
Rams |
at |
Seahawks |
Sunday, January 2, 2011 |
8:20PM |
STL 6, SEA 16 |