| Regular Season: Week 1 |
 Bears |
at |
 Rams |
Sunday, September 12, 2021 |
8:20PM |
CHI 14, LAR 34 |
| Regular Season: Week 2 |
Rams |
at |
 Colts |
Sunday, September 19, 2021 |
1:00PM |
LAR 27, IND 24 |
| Regular Season: Week 3 |
 Buccaneers |
at |
Rams |
Sunday, September 26, 2021 |
4:25PM |
TB 24, LAR 34 |
| Regular Season: Week 4 |
 Cardinals |
at |
Rams |
Sunday, October 3, 2021 |
4:05PM |
ARI 37, LAR 20 |
| Regular Season: Week 5 |
Rams |
at |
 Seahawks |
Thursday, October 7, 2021 |
8:20PM |
LAR 26, SEA 17 |
| Regular Season: Week 6 |
Rams |
at |
 Giants |
Sunday, October 17, 2021 |
1:00PM |
LAR 38, NYG 11 |
| Regular Season: Week 7 |
 Lions |
at |
Rams |
Sunday, October 24, 2021 |
4:05PM |
DET 19, LAR 28 |
| Regular Season: Week 8 |
Rams |
at |
 Texans |
Sunday, October 31, 2021 |
1:00PM |
LAR 38, HOU 22 |
| Regular Season: Week 9 |
 Titans |
at |
Rams |
Sunday, November 7, 2021 |
8:20PM |
TEN 28, LAR 16 |
| Regular Season: Week 10 |
Rams |
at |
 49ers |
Monday, November 15, 2021 |
8:15PM |
LAR 10, SF 31 |
| Regular Season: Week 12 |
Rams |
at |
 Packers |
Sunday, November 28, 2021 |
4:25PM |
LAR 28, GB 36 |
| Regular Season: Week 13 |
 Jaguars |
at |
Rams |
Sunday, December 5, 2021 |
4:25PM |
JAX 7, LAR 37 |
| Regular Season: Week 14 |
Rams |
at |
Cardinals |
Monday, December 13, 2021 |
8:15PM |
LAR 30, ARI 23 |
| Regular Season: Week 15 |
Seahawks |
at |
Rams |
Sunday, December 19, 2021 |
4:25PM |
SEA 10, LAR 20 |
| Regular Season: Week 16 |
Rams |
at |
 Vikings |
Sunday, December 26, 2021 |
1:00PM |
LAR 30, MIN 23 |
| Regular Season: Week 17 |
Rams |
at |
 Ravens |
Sunday, January 2, 2022 |
4:25PM |
LAR 20, BAL 19 |
| Regular Season: Week 18 |
49ers |
at |
Rams |
Sunday, January 9, 2022 |
4:25PM |
SF 27, LAR 24 |